Results 41 to 50 of about 222,573 (269)

International Journal of Neuropsychopharmacology / Making Sense of : Sensitization in Schizophrenia [PDF]

, 2016
Sensitization is defined as a process whereby repeated intermittent exposure to a given stimulus results in an enhanced response at subsequent exposures. Next to robust findings of an increased dopamine synthesis capacity in schizophrenia, empirical data
Weidenauer, Ana, Lucie Bartova, Ana Weidenauer, Harald H. Sitte, Willeit, Matthäus, Ulrich Sauerzopf, Bauer, Martin, Bartova, Lucie, Kasper, Siegfried, Matthäus Willeit, Praschak-Rieder, Nicole, Nicole Praschak-Rieder, Sauerzopf, Ulrich, Siegfried Kasper, Sitte, Harald H., Martin Bauer   +15 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

PSYNDEX Tests Review für RSCI - Repression-Sensitization-Coping-Inventar [PDF]

, 1997
This is a PSYNDEX Tests Review of RSCI - Repression-Sensitization-Coping-Inventar. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Weiderer, Monika
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs) [PDF]

Osteoarthritis (OA) pain is associated with structural changes in the joint, which are usually quantified by imaging techniques. It is anticipated that structural disease modifying OA drugs (DMOADs) would reduce the burden of OA pain.
McWilliams, Daniel F, Walsh, David A
core   +2 more sources

Concomitant sensitization to glutaraldehyde and methacrylic monomers among dentists and their patients [PDF]

, 2016
Background: A multitude of methacrylic monomers is used in dentistry. Glutaraldehyde (G) is used in dental practice and consumer products as a broad-spectrum antimicrobial agent.
Assya Krasteva-Panova, Dencheva, Maria, Maria Dencheva, Lyapina, Maya G., Angelina Kisselova-Yaneva, Mariana Tzekova-Yaneva, Maya Lyapina, Kisselova-Yaneva, Angelina, Krasteva-Panova, Assya, Mariela Deliverska, Tzekova-Yaneva, Mariana, Maya Grigorievna Lyapina, Deliverska, Mariela   +12 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Skin Sensitization Testing Using New Approach Methodologies [PDF]

Skin sensitization, representing one of the regulatory toxicity endpoints, is seeing significant progress in the uptake of new approach methodologies, comprising non-animal evaluations, to provide regulatory and product development information on ...

core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source