Results 51 to 60 of about 584,493 (306)
Frontiers in Behavioral Neuroscience, 2020 Sensation seeking is a heritable trait that is genetically correlated with substance use; the shared genetic mechanisms underlying these traits are largely unknown.
Price E. Dickson, Guy Mittleman
doaj +1 more source
Modern Principles of Managing Children with Food Allergies
Педиатрическая фармакология, 2021 The article presents modern data on the epidemiology, etiology and clinical manifestations of food allergies in children. Evidence-based approaches to diagnosis, including differential, treatment, and prevention of food allergies in children are shown ...
Alexander A. Baranov +16 more
doaj +1 more source
Increased risk of horse sensitization in southwestern Iranian horse riders [PDF]
, 2015 Objectives: The aim of this study has been to investigate the frequency of sensitization to horse allergens and clinical symptoms in horse riders. Material and Methods: A total of 42 horse riders and 50 healthy individuals were examined by means of skin ...
Zeynab Hosseini +7 more
core +2 more sources
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Materials Research ExpressThis study presents four Gaussian-based mathematical models for accurately simulating the sensitization and desensitization processes in austenitic alloys.
Parag M Ahmedabadi
doaj +1 more source
Seminars in Reproductive Medicine, 2017 Chronic pelvic pain is a frustrating symptom for patients with endometriosis and is frequently refractory to hormonal and surgical management. While these therapies target ectopic endometrial lesions, they do not directly address pain due to central ...
J. Aredo +4 more
semanticscholar +1 more source
Inflammatory response and IgE sensitization at early age
, 2013 Microbial exposure may induce low-grade inflammation at an early age and decrease the risk of allergic diseases, as suggested by the hygiene hypothesis.
Roduit, Caroline; https://orcid.org/ +35 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Use of the painDETECT tool in rheumatoid arthritis suggests neuropathic and sensitization components in pain reporting. [PDF]
, 2014 Rheumatoid arthritis (RA) is an inflammatory autoimmune condition typified by systemic inflammation targeted toward synovial joints. Inhibition of proinflammatory networks by disease-modifying antirheumatic drugs, eg, methotrexate and biologic therapies,
Sofat, N +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source