Results 81 to 90 of about 265,697 (314)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Amelioration of cisplatin sensitivity in human cervical cancer: Epigallocatechin-3-Gallate

Frontiers in Nutrition, 2015
Cisplatin is one of the effective chemotherapeutics in the treatment of several types of cancers. However, in addition to the efforts against to its toxicity, the amelioration of cisplatin sensitivity is an important point in treatment of cervical cancer.
Ulkan eKilic, Kazim eSahin, Mehmet eTuzcu, Nazli eBasak, Cemal eOrhan, Birsen eElibol-Can, Ertugrul eKilic, Fikrettin eSahin, Omer eKucuk   +8 more
doaj   +1 more source

Evolving Sensitivity [PDF]

ACS Chemical Biology, 2006
Engineering gene circuits with novel functions holds promise for broad applications in biology, engineering, and medicine. Directed evolution complements rational design as an important strategy for optimizing gene circuits and circuit elements.
Hao, Song, Lingchong, You
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Staphylococcus aureus enterotoxin sensitization is associated with allergic poly-sensitization and allergic multimorbidity in adolescents

, 2017
Background: Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromso Study Fit Futures 2, we have previously shown an association between S.
C. Bachert, Furberg, A-S, Klingenberg, C., Sollid, JUE, Bachert, Claus, Bousquet, J., M. Sørensen, Wickman, M, Furberg, C, Wickman, M., J. U. E. Sollid, Solid, J.U.E., Klingenberg, C, Bachert, C., J. Bousquet, Sørensen, M., M. Wickman, Sørensen, M, C. Klingenberg, A-S. Furberg, Bousquet, J, Sorensen, M, Wickman, M,, Bachert, C,   +23 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Sensitization and its impact on Reproductive and sexual health issues of adolescents in clinics and schools - a comparative study.

Asian Journal of Medical Sciences, 2011
Objective: Adolescent Reproductive and Sexual Health Issue is an important component of Youth Friendly Health Services. The objective of this study to compare the impact of sensitization on adolescent reproductive and sexual health issues of adolescent ...
Arun Kumar De
doaj   +1 more source

Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens [PDF]

, 2009
BACKGROUND Allergy diagnosis needs to be improved in patients suffering from pollen polysensitization due to the existence of possible confounding factors in this type of patients.
Barber, Domingo, Rodriguez, R., Davila, I., Lombardero, M., Salcedo Duran, Gabriel, Colas, C., Torre, F. de la, Villalba, M., Antepara, I., Tabar, I.A., Vidal, C.   +10 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Electronic properties study of sensitizing centers in chemical sensitization [PDF]

, 2004
Reduction sensitization, sulfur sensitization and sulfur-plus-gold sensitization are ...
Tan, Ji
core