Results 81 to 90 of about 735,970 (407)

Domain-sensitivity

Synthese, 2010
In this paper, I argue that there are good motivations for a relativist account of the domain-sensitivity of quantifier phrases. I will frame the problem as a puzzle involving what looks like a logically valid inference, yet one whose premises are true while the conclusion is false. After discussing some existing accounts, literalist and contextualist,
openaire   +3 more sources

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens

, 2009
BACKGROUND Allergy diagnosis needs to be improved in patients suffering from pollen polysensitization due to the existence of possible confounding factors in this type of patients.
Antepara, I., Barber, Domingo, Colas, C., Davila, I., Lombardero, M., Rodriguez, R., Salcedo Duran, Gabriel, Tabar, I.A., Torre, F. de la, Vidal, C., Villalba, M.   +10 more
core   +1 more source

The mode of sensitization and its influence on allograft outcomes in highly sensitized kidney transplant recipients.

Nephrology, Dialysis and Transplantation, 2016
BACKGROUND We sought to determine whether the mode of sensitization in highly sensitized patients contributed to kidney allograft survival. METHODS An analysis of the United Network for Organ Sharing dataset involving all kidney transplants between ...
R. Redfield, J. Scalea, Tiffany J Zens, D. Mandelbrot, G. Leverson, D. Kaufman, A. Djamali   +6 more
semanticscholar   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile–Young Adult Rats

Microorganisms, 2019
Increased intestinal permeability is thought to underlie the pathogenesis of food allergy. We explore the mechanism responsible for changes in the morphology and function of the intestinal barrier using a rat model of food allergy, focusing on the ...
Janyerkye Tulyeu, Hideki Kumagai, Eriko Jimbo, Shinya Watanabe, Koji Yokoyama, Longzhu Cui, Hitoshi Osaka, Makiko Mieno, Takanori Yamagata   +8 more
doaj   +1 more source

On Block Sensitivity and Fractional Block Sensitivity [PDF]

Lobachevskii Journal of Mathematics, 2018
We investigate the relation between the block sensitivity $\text{bs}(f)$ and fractional block sensitivity $\text{fbs}(f)$ complexity measures of Boolean functions. While it is known that $\text{fbs}(f) = O(\text{bs}(f)^2)$, the best known separation achieves $\text{fbs}(f) = \left(\frac{1}{3\sqrt2} +o(1)\right) \text{bs(f)}^{3/2}$.
Jevgēnijs Vihrovs, Andris Ambainis, Krišjānis Prūsis   +2 more
openaire   +3 more sources

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Molecular and cellular dynamics of the Toll-like receptor 4 pathway.

Frontiers in Immunology, 2014
As well as being the primary signaling receptor for bacterial endotoxin or lipopolysaccharide Toll-like receptor 4 function is modulated by numerous factors not only in the context of microbial pathogenesis but also autoimmune and allergic diseases. TLR4
Nick eGay, Ardiyanto eLiaunardy-Jopeace, Ardiyanto eLiaunardy-Jopeace   +2 more
doaj   +1 more source

Molecular profile of sensitization in subjects with short occupational exposure to latex [PDF]

, 2015
Objectives: We examined the prevalence of latex allergy in subjects with occupational exposure to latex allergens for less than 5 years, determining the disease spectrum in symptomatic workers.
Buonanno, Rosaria, Crispino, Vincenzo, DI CARLO, Angelina, Di Domenico, Marina, Feola, Antonia, Giovane, Giancarlo, Lamberti, Monica, Medici, Nicola, Ritonnaro, Chiara, Sannolo, Nicola   +9 more
core   +3 more sources