Results 161 to 170 of about 2,923,375 (341)

Framework for a space shuttle main engine health monitoring system [PDF]

A framework developed for a health management system (HMS) which is directed at improving the safety of operation of the Space Shuttle Main Engine (SSME) is summarized.
Galinaitis, William S., Hawman, Michael W., Kamenetz, Jeffrey, Mattedi, Anita K., Tulpule, Sharayu   +4 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Research on Locomotive Speed Sensor Fault Diagnosis Method Based on Neural Network

机车电传动, 2010
For fault diagnosis of locomotive speed sensor, a predictor method based on RBF neural network is established, and diagnostic decision method is also proposed.
周桂法, 王坚
doaj  

Sensor Fault-Tolerant Control of Microgrid Using Robust Sliding-Mode Observer. [PDF]

Sensors (Basel), 2022
Shahzad E, Khan AU, Iqbal M, Saeed A, Hafeez G, Waseem A, Albogamy FR, Ullah Z.   +7 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Sensor Fault Diagnosis Using a Machine Fuzzy Lyapunov-Based Computed Ratio Algorithm. [PDF]

Sensors (Basel), 2022
TayebiHaghighi S, Koo I.
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Real-Time Sensor Fault Tolerant Control of DC-DC Converters in DC Microgrids Using a Switching Unknown Input Observer

IEEE Access
DC Microgrids are rapidly developing, driven by the increasing integration of renewable sources and dynamic loads. Their growing adoption in critical applications raises the need for operational safety and reliability, particularly under fault conditions.
Mohammed Said Ouahabi, Abdelhafid Benyounes, Said Barkat, Syphax Ihammouchen, Toufik Rekioua, Abdelaziz Rabehi, El-Sayed M. El-Kenawy, Amal H. Alharbi   +7 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Actuator and sensor fault isolation in a class of nonlinear dynamical systems

Journal of Automation and Intelligence
Fault isolation in dynamical systems is a challenging task due to modeling uncertainty and measurement noise, interactive effects of multiple faults and fault propagation.
Hamed Tirandaz, Christodoulos Keliris, Marios M. Polycarpou   +2 more
doaj   +1 more source