Results 181 to 190 of about 2,410,060 (338)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Sensorial function in children with congenital Zika syndrome: what is the relationship with motor function? [PDF]

Rev Paul Pediatr
Brito ASS, Meira CAC, Moreira KMA, Santino TA, Tavares JS, Gama GL, Melo A.   +6 more
europepmc   +1 more source

AESTHETICS CONFERS VALUE TO THE FIRM [PDF]

The aesthetics offers multiple, powerful, specific and tangible advantages to the firm such as: it creates fidelity; it expresses the personality of the firm and of its marks; it allows the establishment of superior prices; the aesthetics message ...
Flaviu Meghisan, Gheorghe Meghisan
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Eco-feminismo en la narrativa surrealista de María Luisa Bombal

Cuadernos del CILHA
Este trabajo presenta un análisis de tres cuentos de Maria Luisa Bombal: "El árbol", "Las islas nuevas" y "La historia de María Griselda" usando el concepto de écriture féminine de Hélène Cixous y el de eco-feminismo, según Ress y Warren.
Zoila Yovanna Clark
doaj  

Effect of multi-dimensional sensory touch and family-accompanied whole-process nursing on feeding intervention for preterm infants. [PDF]

Rev Esc Enferm USP
Ye T, Gao L.
europepmc   +1 more source

Sensory Inattention [PDF]

The Permanente Journal, 2018
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Development and Characterisation of Pasta Enriched with Carrot Powder. [PDF]

Foods
Florença SG, Ferrão AC, Costa FP, Guiné RPF.   +3 more
europepmc   +1 more source