Results 111 to 120 of about 338,560 (308)

Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain [PDF]

, 2017
Richard Salvi, Wei Sun, Dalian Ding, Guang-Di Chen, Edward Lobariñas, Jian Wang, Kelly E. Radziwon, Benjamin D. Auerbach   +7 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Experiences of people with dual sensory loss in various areas of life: A qualitative study. [PDF]

PLoS One, 2023
Veenman E, Roelofs AAJ, Stolwijk ML, Bootsma AM, van Nispen RMA.   +4 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19–positive patients compared to subjective methods: A systematic review and meta-analysis [PDF]

, 2020
Mackenzie E. Hannum, Vicente A Ramirez, Sarah J. Lipson, Riley D Herriman, Aurora K Toskala, Cailu Lin, Paule V. Joseph, Danielle R. Reed   +7 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Critical quality appraisal and algorithm development of clinical practice guidelines for management of poststroke sensory loss: a systematic review. [PDF]

BMJ Open, 2023
Li X, Xing X, Yao N.
europepmc   +1 more source

Impact of the COVID-19 pandemic on social isolation in older adults with sensory loss

, 2021
Yueh-Hsun Wu, Peggy B. Nelson, Kristi Oeding, Elizabeth Anderson, Katherine Teece, Chris Curry, Jinseok Oh, Rachel Gage, Gordon E. Legge   +8 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Regressive changes in sizes of somatosensory cuneate nucleus after sensory loss in primates. [PDF]

Proc Natl Acad Sci U S A, 2023
Qi HX, Reed JL, Liao CC, Kaas JH.
europepmc   +1 more source