Results 101 to 110 of about 396,805 (256)

Differential conservation analysis identifies residues defining constitutive internalization in beta-adrenergic receptors

iScience
Summary: G protein-coupled receptors (GPCRs) are major drug targets and key regulators of cell signaling. The basis of functional diversification between individual GPCRs and families of GPCRs can be revealed by investigating evolutionary conservation ...
Abigail Rose Walker, Berkay Selçuk, Ismail Erol, Serdar Durdağı, Aylin Carla Hanyaloglu, Ogün Adebali   +5 more
doaj   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation

iScience
Summary: Acute alcohol can have profound effects on the brain and behavior. Dorsal medial prefrontal cortex (dmPFC) function is especially sensitive to disruption from acute alcohol exposure.
Kathleen G. Bryant, David Swygart, Yuexi Yin, Meredith R. Bauer, Mitchell D. Morningstar, Nicholas M. Timme, William H. Barnett, Colleen E. McGonigle, Eric A. Engleman, Patrick L. Sheets, Christopher C. Lapish   +10 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Automated sleep staging from single-channel electroencephalogram using hybrid neural network with manual features and attention

iScience
Summary: Sleep staging is essential for evaluating sleep quality, diagnosing disorders, and creating personalized treatment plans. The convolutional and bidirectional long short-term memory hybrid neural network (CNN-BiLSTM) has shown promise in ...
Qingyun Wan, Yuyang Bo, Ying Zhang, Mufeng Li, Xiaoqiu Wang, Chuang Chen, Lanying Liu, Wenzhong Wu   +7 more
doaj   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Frequency-tagging EEG reveals spontaneous categorical discrimination of visual self-identity

iScience
Summary: From early development, visual and sensorimotor representations of our hands are continually linked, allowing to develop a bodily self-representation.
Mattia Galigani, Nicolò Castellani, Barbara Italia, Sveva D’Aversa, Davide Bottari, Francesca Garbarini   +5 more
doaj   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Inhibitory inputs from thalamus promote resilient spiking in tail of striatum

iScience
Summary: Thalamic afferents form glutamatergic synapses with striatal medium spiny neurons (MSNs). These projections are involved in complex learning processes and have primarily been studied in rostral striatum. Caudal regions, such as tail of striatum (
Laura M. Haetzel, Jan Gründemann
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source