Results 121 to 130 of about 193,431 (304)

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Neural basis of a visuo-motor transformation in the fly

, 2009
How the outputs of populations of sensory neurons are used by motor systems to generate appropriate behaviour is a long standing question in neuroscience. I address this problem by studying a comparatively simple model system.

core   +1 more source

Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations

iScience
Summary: Accurate perception of objects within the environment independent of context is essential for the survival of an organism. While neurons that respond in an invariant manner to different stimulus waveforms resulting from identitypreserving ...
Michael G. Metzen, Amin Akhshi, Pouya Bashivan, Anmar Khadra, Maurice J. Chacron   +4 more
doaj   +1 more source

The Sensory Ecology of Tsetse Flies: Neuroscience Perspectives on a Disease Vector

European Journal of Neuroscience
ABSTRACT Tsetse flies ( Glossina sp.) are important disease vectors with unique biology that makes them fascinating models to study the evolution of behaviour and its underlying neural circuits.
Andrea Adden, Lucia L. Prieto‐Godino
openaire   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Hierarchical organization of the forebrain cholinergic system in rats

iScience
Summary: The basal forebrain (BF) cholinergic system (BFCS) participates in functions that are global across the brain, such as sleep-wake cycles, but also participates in capacities that are more behaviorally and anatomically specific, including sensory
Peter Varsanyi, Kevin Alloway, Candice Chavez, Matthew R. Gielow, Peter Gombkoto, Hideki Kondo, Zoltan Nadasdy, Laszlo Zaborszky   +7 more
doaj   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source

Spatiotemporal properties of cortical excitatory and inhibitory neuron activation by sustained and bursting electrical microstimulation

iScience
Summary: Intracortical microstimulation (ICMS) of sensory brain regions can create artificial sensations, yet these percepts fade with continued stimulation, suggesting dynamic changes in underlying neural activity. Using two-photon imaging in transgenic
Christopher L. Hughes, Kevin C. Stieger, Keying Chen, Alberto L. Vazquez, Takashi D.Y. Kozai   +4 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Echoes from Sensory Entrainment in Auditory Working Memory for Pitch

Ongoing neural oscillations reflect cycles of excitation and inhibition in local neural populations, with individual neurons being more or less likely to fire depending upon the oscillatory phase.
Matthew G. Wisniewski
core   +1 more source