Results 111 to 120 of about 946,105 (288)

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Diagram for Neuroscience journal article [PDF]

, 2018
A new hypothesis relating ADHD and mind wandering, was published as a journal article 'Mind wandering perspective on attention-deficit/hyperactivity disorder'.
Bozhilova, Natali Stanimirova, Bozhilova, Natali, Michelini, Giorgia; id_orcid, Michelini, G, Kuntsi, Jonna; id_orcid, Asherson, P, Bozhilova, NS, Tan, Kai Syng, Kuntsi, J, Asherson, Philip; id_orcid   +9 more
core   +1 more source

Highlights in basic autonomic neuroscience: Contribution of the urothelium to sensory mechanisms in the urinary bladder [PDF]

Autonomic Neuroscience, 2013
Urothelial cells in the urinary bladder express neural properties including: (1) release of neurotransmitters and neurotrophic factors, (2) expression of neurotransmitter receptors and ion channels, and (3) sensitivity to mechanical and chemical stimuli.
openaire   +2 more sources

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Development of a neurophysiological sensory gating model in the rat to aid in the preclinical identification of possible treatments of sensory flooding in schizophrenia [PDF]

, 2013
Objective: It has been widely hypothesized that a failure to properly filter, or ‘gate’, incoming auditory information occurs in schizophrenic patients. This can be observed in a reduced event-related potential response to the second of a pair of clicks,
Bloomfield, Andrew
core   +2 more sources

Retrospective case-control study of pre-diagnosis observational and prescription data in Parkinson’s disease

Scientific Reports
There are currently no disease-modifying treatments for Parkinson’s disease. Retrospective analysis of routinely collected health data may enable earlier risk detection and identify therapeutic candidates for drug repurposing.
Patrick Doherty, Susan Duty, Gareth Williams   +2 more
doaj   +1 more source

Segregated input to thalamic areas that project differently to core and shell auditory cortical fields

iScience
Summary: Perception of the environment is multimodal in nature, with sensory systems intricately interconnected. The ability to integrate multimodal sensations while preserving the distinct characteristics of each sensory modality is crucial, and the ...
Tetsufumi Ito, Mamiko Yamamoto, Li Liu, Khaleeq Ahmad Saqib, Takafumi Furuyama, Munenori Ono   +5 more
doaj   +1 more source

David Julius and Ardem Patapoutian: Pioneers in Sensory Biology and Neuroscience

Cureus
Sensory biology is a critical area within neuroscience, exploring how organisms respond to environmental stimuli such as temperature, pain, and mechanical forces. David Julius and Ardem Patapoutian have made landmark contributions to this field by identifying crucial receptors.
Rukadikar, Charushila, Charulata, Kadam, Dipankar, Satish P, Nisargandha, Milind A   +3 more
openaire   +2 more sources

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source