Results 111 to 120 of about 193,431 (304)

Inhibitory inputs from thalamus promote resilient spiking in tail of striatum

iScience
Summary: Thalamic afferents form glutamatergic synapses with striatal medium spiny neurons (MSNs). These projections are involved in complex learning processes and have primarily been studied in rostral striatum. Caudal regions, such as tail of striatum (
Laura M. Haetzel, Jan Gründemann
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Decline in Sensory Integration in Old Age and Its Related Functional Brain Connectivity Correlates Observed during a Virtual Reality Task

Sensory integration is an essential human function whose decline impacts quality of life, particularly in older adults. Herein, we propose an arm-reaching task based on a virtual reality head-mounted display system to assess sensory integration in daily ...
Ludovico Minati, Natsue Yoshimura, Satoru Inagaki, Kazuki Sakurai, Hirokazu Matsuura   +4 more
core   +1 more source

Human pairs show collective benefit in olfactory perception despite individual differences and verbal limits

iScience
Summary: Olfaction is a limit case for human communication. Not only does genetic, personal, and cultural diversity make us smell things differently, but perceptual and neurological factors are meant to make it challenging to verbalize our olfactory ...
Mustafa Yavuz, Saman Sayahpour, Bahador Bahrami, Ophelia Deroy   +3 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Bursts of vagus nerve stimulation paired with auditory rehabilitation fail to improve speech sound perception in rats with hearing loss

iScience
Summary: Hearing loss can lead to long-lasting effects on the central nervous system, and current therapies, such as auditory training and rehabilitation, show mixed success in improving perception and speech comprehension.
Alan M. Carroll, Jonathan R. Riley, Michael S. Borland, Tanya T. Danaphongse, Seth A. Hays, Michael P. Kilgard, Crystal T. Engineer   +6 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Sensory disturbances in complex regional pain syndrome: Clinical observations, autonomic interactions, and possible mechanisms

, 2010
To review mechanisms that might contribute to sensory disturbances and sympathetically-maintained pain in complex regional pain syndrome (CRPS). CRPS is associated with a range of sensory and autonomic abnormalities.
Drummond, P.D.
core  

Effects of corticothalamic feedback depend on visual responsiveness and stimulus type

iScience
Summary: In the dorsolateral geniculate nucleus (dLGN) of the thalamus, stimulus-driven signals combine with modulatory inputs such as corticothalamic (CT) feedback and behavioral state, but their impact in shaping dLGN activity is debated.
Lisa Schmors, Ann H. Kotkat, Yannik Bauer, Ziwei Huang, Davide Crombie, Lukas Sebastian Meyerolbersleben, Sacha Sokoloski, Philipp Berens, Laura Busse   +8 more
doaj   +1 more source

Highlights in basic autonomic neuroscience: Contribution of the urothelium to sensory mechanisms in the urinary bladder [PDF]

Autonomic Neuroscience, 2013
Urothelial cells in the urinary bladder express neural properties including: (1) release of neurotransmitters and neurotrophic factors, (2) expression of neurotransmitter receptors and ion channels, and (3) sensitivity to mechanical and chemical stimuli.
openaire   +2 more sources