Results 91 to 100 of about 526,955 (247)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system. [PDF]

Front Mol Neurosci, 2023
Takanami K, Kuroiwa M, Ishikawa R, Imai Y, Oishi A, Hashino M, Shimoda Y, Sakamoto H, Koide T.   +8 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

“Augmented Reality” in Martial: The Use and the Abuse of Olfactory and Gustatory Systems in Martial’s Epigrams

Humanitas
This paper examines Martial's innovative use of the senses of smell and taste in his epigrams, revealing how he transcends the limitations of the written word by inviting readers to interact with his work on a visceral level.
David Israel
doaj   +1 more source

The Effects of Sensory Flow on The Autonomic Nervous System [PDF]

, 2019
Jessica Keller
openalex   +1 more source

Correlation of visual system biomarkers with motor-sensory deficits in experimental autoimmune encephalomyelitis-optic neuritis [PDF]

, 2023
Benjamin W. Elwood, Cheyanne R. Godwin, Jeffrey J. Anders, Randy H. Kardon, Oliver W. Gramlich   +4 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The impact of sleep deprivation on the functional connectivity of auditory-related brain regions

Brain Research Bulletin
This study explored the effects of 36-hour acute sleep deprivation on the functional connectivity of auditory-related brain regions in healthy young males, examining its associations with alertness and emotional states.
Peng Zhang, Kai Wen, Huifeng Liu, Jing Wang, Qin Han, Fangfang Liu, Xiechuan Weng, Fan Xu   +7 more
doaj   +1 more source

Sensory system-specific associations between brain structure and balance. [PDF]

Neurobiol Aging, 2022
Hupfeld KE, McGregor HR, Hass CJ, Pasternak O, Seidler RD.   +4 more
europepmc   +1 more source

Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections

, 2023
Claire Wyart, Kin Ki Jim, Andrew Prendergast   +2 more
openalex   +2 more sources