Results 111 to 120 of about 1,263,682 (340)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

eLife, 2015
In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify primary
Andreas Zembrzycki, Adam M Stocker, Axel Leingärtner, Setsuko Sahara, Shen-Ju Chou, Valery Kalatsky, Scott R May, Michael P Stryker, Dennis DM O'Leary   +8 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Multidimensional MRI-CT atlas of the naked mole-rat brain

Frontiers in Neuroanatomy, 2013
Naked mole-rats have a variety of distinctive features such as the organisation of a hierarchical society (known as eusociality), extraordinary longevity, and cancer resistance; thus, it would be worthwhile investigating these animals in detail.
Fumiko eSeki, Fumiko eSeki, Keigo eHikishima, Keigo eHikishima, Sanae eNambu, Kazuo eOkanoya, Kazuo eOkanoya, Hirotaka James Okano, Erika eSasaki, Erika eSasaki, Kyoko eMiura, Kyoko eMiura, Hideyuki eOkano, Hideyuki eOkano   +13 more
doaj   +1 more source

A robotic sensory system with high spatiotemporal resolution for texture recognition. [PDF]

Nat Commun, 2023
Bai N, Xue Y, Chen S, Shi L, Shi J, Zhang Y, Hou X, Cheng Y, Huang K, Wang W, Zhang J, Liu Y, Guo CF.   +12 more
europepmc   +1 more source

Real-time motor rotation frequency detection with event-based visual and spike-based auditory AER sensory integration for FPGA [PDF]

, 2015
Multisensory integration is commonly used in various robotic areas to collect more environmental information using different and complementary types of sensors. Neuromorphic engineers mimics biological systems behavior to improve systems performance
Cerezuela Escudero, Elena, Domínguez Morales, Manuel Jesús, Jiménez Fernández, Ángel Francisco, Jiménez Moreno, Gabriel, Linares Barranco, Alejandro, Ríos Navarro, José Antonio   +5 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Muscularity of Mind: Towards an Explanation of the Transition from Unconscious to Conscious [PDF]

, 2005
The title “Muscularity of Mind” indicates the point of view that is argued in this essay. I attempt to trace the roots of higher cognitive abilities to the physiological coupling that exists between neuro-sensory and muscular system.
G., Nagarjuna
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Distributed intelligent robotics : research & development in fault-tolerant control and size/position identification : a thesis presented in partial fulfilment of the requirements for the degree of Master of Engineering in Computer Systems Engineering at Massey University [PDF]

, 2002
This thesis presents research conducted on aspects of intelligent robotic systems. In the past two decades, robotics has become one of the most rapidly expanding and developing fields of science.
Subramaniam, Karthikeya Krishna
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