Results 121 to 130 of about 1,263,682 (340)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Structure‐Dependent Resonant Frequency Engineering of Textile Tactile Sensors Toward Rapid and Precise Braille Recognition Surpassing Human Sensation

Advanced Science
Artificial tactile perception emulating slow‐(SA) and fast‐adapting (FA) mechanoreceptors is crucial for visually impaired individuals as an advanced auxiliary learning electronic system. However, existing sensors, particularly single‐mode ones, struggle
Xianhong Zheng, Runrun Zhang, Yu Shi, Zhao Zhang, Guiyang Li, Zhengliang Shang, Xin Liu, Fan Zhao, Sheng Hu, Ran Xu, Shuai Wang, Zhiqi Zhao, Zhi Liu, Lihua Zou, Xu Han, Zongqian Wang, Wei Huang, Gengzhi Sun   +17 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

How the sensory system of carnivorous plants has evolved. [PDF]

Plant Commun, 2022
Pavlovič A.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Sensory Input from the External Cuneate Nucleus and Central Cervical Nucleus to the Cerebellum Refines Forelimb Movements

Cells
Goal-directed reaching movements are extremely accurate to the point that the location, placement, and speed of the limbs are specific from trial to trial.
Chidubem Eneanya, George M. Smith
doaj   +1 more source

Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system. [PDF]

Front Mol Neurosci, 2023
Takanami K, Kuroiwa M, Ishikawa R, Imai Y, Oishi A, Hashino M, Shimoda Y, Sakamoto H, Koide T.   +8 more
europepmc   +1 more source

Hierarchical control of intelligent machines applied to space station telerobots [PDF]

A hierarchical architecture is described which supports space station telerobots in a variety of modes. The system is divided into three hierarchies: task decomposition, world model, and sensory processing.
Albus, J. S., Lumia, R., Mccain, H.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

SDRL: Interpretable and Data-efficient Deep Reinforcement Learning Leveraging Symbolic Planning

, 2019
Deep reinforcement learning (DRL) has gained great success by learning directly from high-dimensional sensory inputs, yet is notorious for the lack of interpretability.
Gustafson, Steven, Liu, Bo, Lyu, Daoming, Yang, Fangkai   +3 more
core   +1 more source