Results 121 to 130 of about 26,200,033 (292)

The impact of sleep deprivation on the functional connectivity of auditory-related brain regions

Brain Research Bulletin
This study explored the effects of 36-hour acute sleep deprivation on the functional connectivity of auditory-related brain regions in healthy young males, examining its associations with alertness and emotional states.
Peng Zhang, Kai Wen, Huifeng Liu, Jing Wang, Qin Han, Fangfang Liu, Xiechuan Weng, Fan Xu   +7 more
doaj   +1 more source

Analysis of the role of the QseBC two-component sensory system in epinephrine-induced motility and intracellular replication of Burkholderia pseudomallei. [PDF]

PLoS One, 2023
Meethai C, Vanaporn M, Intarak N, Lerdsittikul V, Withatanung P, Janesomboon S, Vattanaviboon P, Chareonsudjai S, Wilkinson T, Stevens MP, Stevens JM, Korbsrisate S.   +11 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

“Augmented Reality” in Martial: The Use and the Abuse of Olfactory and Gustatory Systems in Martial’s Epigrams

Humanitas
This paper examines Martial's innovative use of the senses of smell and taste in his epigrams, revealing how he transcends the limitations of the written word by inviting readers to interact with his work on a visceral level.
David Israel
doaj   +1 more source

Evolution of left-right asymmetry in the sensory system and foraging behavior during adaptation to food-sparse cave environments. [PDF]

BMC Biol, 2022
Fernandes VFL, Glaser Y, Iwashita M, Yoshizawa M.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sex-specific evolution of a Drosophila sensory system via interacting cis- and trans-regulatory changes. [PDF]

Evol Dev, 2022
Luecke D, Rice G, Kopp A.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Agent-based modeling reveals how bats navigate dense group emergences

eLife
Bats face a complex navigation challenge when emerging from densely populated roosts, where vast numbers take off at once in dark, confined spaces. Each bat must avoid collisions with walls and conspecifics while locating the exit, all amidst overlapping
Omer Mazar, Yossi Yovel
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source