Results 91 to 100 of about 1,275,418 (346)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Loss of mechanical stress induces synovitis, fibrosis and articular cartilage degeneration via distinct synovial cell subsets

open access: yesScientific Reports
Joint function is impaired by disuse, as well as overuse. However, the underlying mechanisms remain unclear. Here, we elucidate the mechanisms of synovial and cartilage changes using a minimized mechanical stress (MMS) mouse model by combining knee joint
Hisatoshi Ishikura   +15 more
doaj   +1 more source

Intrinsically Motivated Learning of Visual Motion Perception and Smooth Pursuit

open access: yes, 2014
We extend the framework of efficient coding, which has been used to model the development of sensory processing in isolation, to model the development of the perception/action cycle. Our extension combines sparse coding and reinforcement learning so that
Shi, Bertram E.   +3 more
core   +1 more source

Sensorimotor processing for balance in spinocerebellar ataxia type 6. [PDF]

open access: yes, 2015
We investigated whether balance impairments caused by cerebellar disease are associated with specific sensorimotor processing deficits that generalize across all sensory modalities.
Bunn, LM   +4 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A robot hand testbed designed for enhancing embodiment and functional neurorehabilitation of body schema in subjects with upper limb impairment or loss. [PDF]

open access: yes, 2015
Many upper limb amputees experience an incessant, post-amputation "phantom limb pain" and report that their missing limbs feel paralyzed in an uncomfortable posture.
Eric eChang   +5 more
core   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Synthesis and evaluation of the smart electric powered wheelchair route stabilization concept – a simulation study

open access: yesArchives of Control Sciences, 2015
The paper addresses the problem of algorithm synthesis for controlling the motion of an electric powered wheelchair. The aim of the algorithm is to stabilize the wheelchair following a linear path and avoiding obstacles if occurred on its way.
Skrzypczyk Krzysztof   +3 more
doaj   +1 more source

Neuronal Pathways and Synaptic Connexions in the Abdominal Cord of the Crayfish [PDF]

open access: yes, 1959
1. An investigation has been made into the function and distribution of nerve fibres in the abdominal ganglion chain and its roots in the crayfish, Procambarus clarkii, by leading off action potentials from small prepared bundles following sensory ...
Hughes, G. M., Wiersma, C. A. G.
core   +1 more source

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