Results 51 to 60 of about 119,484 (277)

The Effect of Granisetron on Sensory Detection and Pain Thresholds in Facial Skin of Healthy Young Males

Frontiers in Neurology, 2020
Background: The specific serotonin type 3 (5-HT3)-receptor antagonist granisetron effectively reduces clinical as well as experimental muscle pain and hyperalgesia and with a duration that exceeds that of lidocaine.
Malin Ernberg, Anna Wieslander Fältmars, Milad Hajizadeh Kopayeh, Sofia Arzt Wallén, Therese Cankalp, Nikolaos Christidis   +5 more
doaj   +1 more source

Inhibition of current perception thresholds in A-delta and C fibers through somatosensory stimulation of the body surface

Scientific Reports, 2022
Somatosensory stimulation of the body surface, such as through tactile and noxious stimulation, is widely known to inhibit pain. However, no studies have measured the threshold changes due to somatosensory stimulation of each nerve fiber (Aβ, Aδ, and C ...
Kazuhiro Shimo, Sho Ogawa, Yuto Niwa, Yuji Tokiwa, Ayaka Dokita, Sho Kato, Takafumi Hattori, Takako Matsubara   +7 more
doaj   +1 more source

Sustained sensorimotor control as intermittent decisions about prediction errors: Computational framework and application to ground vehicle steering [PDF]

, 2017
A conceptual and computational framework is proposed for modelling of human sensorimotor control, and is exemplified for the sensorimotor task of steering a car. The framework emphasises control intermittency, and extends on existing models by suggesting that the nervous system implements intermittent control using a combination of (1) motor primitives,
arxiv   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Somatosensory abnormalities for painful and innocuous stimuli at the back and at a site distinct from the region of pain in chronic back pain patients. [PDF]

PLoS ONE, 2013
Chronic low back pain (CLBP) was shown to be associated with pathophysiological changes at several levels of the sensorimotor system. Changes in sensory thresholds have been reported but complete profiles of Quantitative Sensory Testing (QST) were only ...
Christian Puta, Birgit Schulz, Saskia Schoeler, Walter Magerl, Brunhild Gabriel, Holger H W Gabriel, Wolfgang H R Miltner, Thomas Weiss   +7 more
doaj   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Study on the improvement of behavior and pain and the mechanism of Yangpafang in subacute Parkinson's disease model mice

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective Explore the therapeutic effect of Yangpafang on behavior and pain in subacute Parkinson's disease (PD) model mice and its possible mechanism. Methods Total 42 specific pathogen⁃free (SPF) C57BL/6J mice were randomly divided into control group ...
SHI Ying, MEI Shan‐shan, WANG Yuan‐ling, XIA A‐long, WANG Xiao‐wei, LI Jun   +5 more
doaj   +1 more source

Effects of Short-term Temperature Change in the Innocuous Range on Histaminergic and Non-histaminergic Acute Itch

Acta Dermato-Venereologica, 2018
While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood.
Zoe Lewis, David N. George, Fiona Cowdell, Henning Holle   +3 more
doaj   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Sensory nerve conduction studies in probable painful neuropathy: comparing surface and near-nerve nerve conduction techniques

BMJ Neurology Open, 2022
Introduction We compared sensory nerve conduction studies (NCS) using surface and near-nerve recording electrodes in 53 patients with clinical probable painful neuropathy.
Martin Ballegaard, Margrethe Bastholm Bille   +1 more
doaj   +1 more source