Results 71 to 80 of about 1,721,455 (251)

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Tactile thresholds in healthy subjects

Zdravniški Vestnik, 2014
Background: The assessment of sensory thresholds provides a method of examining the function of peripheral nerve fibers and their central connections.
Metka Moharić, Gaj Vidmar
doaj  

Perceptual deficits and inattention in schizophrenia [PDF]

, 2008
A number of investigators have found perceptual deficits in schizophrenic subjects. It has also been indicated that those with schizophrenia suffer from reduced attention.
Bernt C. Skottun, John R. Skoyles
core   +2 more sources

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Measuring peripheral nerve involvement in Friedreich’s ataxia

Annals of Clinical and Translational Neurology, 2019
Objective Experimental therapies under development for Friedreich’s Ataxia (FRDA) require validated biomarkers. In‐vivo reflectance confocal microscopy (RCM) of skin is a noninvasive way to quantify Meissner’s corpuscle (MC) density and has emerged as a ...
Peter D. Creigh, Joan Mountain, Janet E. Sowden, Katy Eichinger, Bernard Ravina, Jane Larkindale, David N. Herrmann   +6 more
doaj   +1 more source

Analysis of trigeminal nerve disorders after oral and maxillofacial intervention

Head & Face Medicine, 2010
Background Quantitative sensory testing (QST) is applied to evaluate somatosensory nerve fiber function in the spinal system. This study uses QST in patients with sensory dysfunctions after oral and maxillofacial surgery.
Ghassemi Alireza, Stein Jamal M, Esteves-Oliveira Marcella, Grosjean Maurice B, Koch Felix, Said Yekta Sareh, Riediger Dieter, Lampert Friedrich, Smeets Ralf   +8 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Young children do not integrate visual and haptic information [PDF]

, 2008
Several studies have shown that adults integrate visual and haptic information (and information from other modalities) in a statistically optimal fashion, weighting each sense according to its reliability.
David C. Burr, Giulio Sandini, Michela Del Viva, Monica Gori   +3 more
core   +1 more source

Warm and cold sensory thresholds in patients with unilateral sciatica: C fibers are more severely affected than A‐δ fibers

Acta Neurologica Scandinavica, 1998
Objectives ‐ In order to evaluate if nerve root compression or inflammation is the most important pathogenetic mechanism in lumbar radicular pain, we investigated unmyelinated C‐fiber function (warm sensation) and myelinated A‐delta fiber function (cold ...
J. Zwart, T. Sand, G. Unsgaard
semanticscholar   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source