Results 101 to 110 of about 31,922 (243)

Effects of short‐course preoperative endocrine therapy on tumour morphology and immunohistochemical profile in oestrogen receptor‐positive, HER2‐negative breast cancer

Histopathology, EarlyView.
Short‐course preoperative endocrine therapy induces histopathological and immunophenotypic changes in oestrogen receptor‐positive, HER2‐negative breast cancer. Proliferative response is independently associated with baseline genomic risk (MammaPrint) and progesterone receptor expression.
Claudia Grosse, Alexandra Grosse, Petar Noack, Caroline Ines Preuss, Heike Kathleen Schwarz, Bruno Schneeweiss, Thomas Gitter, Peter Schrenk, Rupert Langer   +8 more
wiley   +1 more source

Long‐term outcome of high‐grade encapsulated papillary carcinoma of the breast: implications for staging and management

Histopathology, EarlyView.
In the original study by Rakha et al., the authors proposed that high‐grade EPC should be considered within an invasive framework regardless of hormone receptor status. In the present study, we adopted a more selective definition of EPC‐A, restricted to tumours showing more adverse features, including high‐grade morphology together with triple‐negative
Milena Stevanovic, Emad Rakha, Ian O. Ellis, Umberto Maccio, Bärbel Papassotiropoulos, Hisham Fansa, Lidija Stevanovic, Heike Frauchiger‐Heuer, Isabell Witzel, Zsuzsanna Varga   +9 more
wiley   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Whole‐slide analysis of mitotic activity in melanoma reveals higher‐proliferation hotspots and distinct spatial patterns

Histopathology, EarlyView.
Whole‐slide analysis of melanoma identified higher‐proliferation mitotic hotspots than routine pathology assessment and revealed distinct spatial patterns of mitotic organization, highlighting the potential of computational mitosis mapping to provide insights beyond conventional mitotic counting.
Shlomo Tsuriel, Batel Gabay, Victoria Hannes, Rami R Hagege, Dov Hershkovitz   +4 more
wiley   +1 more source

The Biological Basis of the Merlin CP‐GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma

International Journal of Dermatology, EarlyView.
Merlin CP‐GEP integrates mechanistic insights into a clinically actionable assay to predict SLN metastasis risk and inform personalized management of cutaneous melanoma. ABSTRACT The recent inclusion of the Merlin clinicopathologic–gene expression profile (CP‐GEP) assay in the National Comprehensive Cancer Network (NCCN) Melanoma Guidelines represents ...
Frank Z. Jing, Alexander Meves
wiley   +1 more source

Contrast enhanced ultrasound of sentinel lymph nodes

Journal of Ultrasonography, 2013
Sentinel lymph nodes are the first lymph nodes in the region that receive lymphatic drainage from a primary tumor. The detection or exclusion of sentinel lymph node micrometastases is critical in the staging of cancer, especially breast cancer and ...
XinWu Cui, Andre Ignee, Michael Bachmann Nielsen, Dagmar Schreiber-Dietrich, Chiara De Molo, Clara Pirri, Maciej Jedrzejczyk, Dietrich F. Christoph   +7 more
doaj  

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Olaparib‐associated cutaneous vasculitis in a patient with breast cancer

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Marcial Álvarez‐Salafranca, Teresa Puértolas, Adrián Diago, María Carmen Gómez‐Mateo   +3 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source