Results 121 to 130 of about 65,190 (266)

Calcification and tumour‐infiltrating lymphocytes predict upgrade of human epidermal growth factor 2 (HER2)‐negative ductal carcinoma in situ diagnosed on core needle biopsy

Histopathology, EarlyView.
With evolving paradigm in treatment of patient diagnosed with pure ductal carcinoma in situ (DCIS), it is essential to stratify patients at low risk for upgrade to invasive disease at subsequent excision to inform management decisions. When combined with adequate sampling and intrinsic tumour characteristics, tumour microenvironment (TME) features ...
Monalyn Marabi, Yuyang Li, Chaiwat Aphivatanasiri, Julia Y Tsang, Joshua JX Li, Lin‐Ying Chen, Gary M Tse   +6 more
wiley   +1 more source

The role of surgery in the treatment of older women with breast cancer

, 2009
A significant proportion of women diagnosed with breast cancer are over the age of 70 years and there is evidence that these patients frequently do not receive standard treatments, including surgical procedures and adjuvant therapies, which would be ...
Audisio, R.A., Reed, M.W.R., Wyld, L.
core   +1 more source

Intrapatient application of lymphoscintigraphy and near-infrared fluorescence in canine and feline sentinel lymph node mapping and removal

BMC Veterinary Research
Background No data regarding near-infrared fluorescence (NIRF) with indocyanine green and its comparison with lymphoscintigraphy are available for sentinel lymph node identification in canine and feline solid malignant tumors.
Elisa Maria Gariboldi, Alessandra Ubiali, Patrizia Boracchi, Ester Luconi, Roberta Ferrari, Luigi Auletta, Donatella De Zani, Davide Danilo Zani, Paola Roccabianca, Valeria Grieco, Chiara Giudice, Camilla Recordati, Damiano Stefanello   +12 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

A Case of Pediatric Spitz Melanoma With a ZEB2::ALK Fusion

Pediatric Dermatology, EarlyView.
ABSTRACT We present a rare case of Spitz melanoma in a 3‐year‐old male patient with a ZEB2::ALK fusion. This ALK‐fused tumor exhibited aggressive behavior, recurring after an initial wide local excision and progressing despite neoadjuvant immunotherapy with a PD‐1 inhibitor.
Nathanael C. Jensen, Shadai Gociman, Sarah D. Cipriano, Casey Mehrhoff   +3 more
wiley   +1 more source

Comparison of Morbidity Between Sentinel Lymph Node Biopsy and Elective Neck Dissection in Dogs With Head and Neck Malignancies

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Elective neck dissection (END) and sentinel lymph node biopsy (SLNB) are suggested for nodal staging of canine head and neck malignancies (HNM). This study aims to compare the morbidity of END to SLNB. Seventy‐six client‐owned dogs with HNM that underwent END (n = 28) or SLNB (n = 48) in two institutions were retrospectively enrolled ...
Lavinia Elena Chiti, Dominique Leu, Roberta Ferrari, Ester Luconi, Patrizia Boracchi, Elisa Maria Gariboldi, Damiano Stefanello, Mirja Christine Nolff   +7 more
wiley   +1 more source

Predictive value of methylene blue combined with indocyanine green in sentinel lymph node metastasis in breast cancer: a prospective pilot cohort study

Frontiers in Oncology
BackgroundThe status of sentinel lymph nodes is crucial for prognosis and treatment decisions in breast cancer patients. This study aimed to evaluate the predictive value of combined methylene blue and indocyanine green for sentinel lymph node metastasis
Zecheng He, Fan Guo, Fan Guo, Yuhan Liu, Yan Lin, Changjun Wang, Yidong Zhou, Qiang Sun   +7 more
doaj   +1 more source

Epidemiology of Four Major Canine Tumours in the UK: Insights From a National Pathology Registry With Comparative Oncology Perspectives

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Pet dogs with naturally occurring cancers provide valuable models for comparative oncology and pathology tumour registries offer a powerful resource for onco‐epidemiological research. Here, we analysed the Small Animal Veterinary Surveillance Network (SAVSNET) pathology‐based tumour registry (PTR), one of the largest veterinary tumour ...
José Rodríguez, Antonio Espinosa de los Monteros, Ángelo Santana, P. J. Noble, Alan D. Radford, Francesco Cian, Annika Herrmann, Jenny S. McKay, Matthew Jones, David R. Killick   +9 more
wiley   +1 more source

Genomic Landscape Analysis of Canine Pulmonary Adenocarcinoma Reveals Candidate Targetable Gene Fusions

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Spontaneously occurring primary canine pulmonary adenocarcinoma (cPAC) exhibits clinicopathological and molecular similarities to never‐smoker human lung cancers. Shared genomic alterations, including point mutations, indel mutations and copy number changes particularly in HER2 signalling, are significant therapeutic targets, especially for ...
Sharadha Sakthikumar, William P. D. Hendricks, David Rainford, William Selleck, Natalia Briones, Christopher Coggins, Natalie Quan, Victoria Zismann, Gwendolen Lorch, Aleksandar Sekulic, Jeffrey M. Trent   +10 more
wiley   +1 more source