Results 111 to 120 of about 1,159,653 (280)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
AIP AdvancesThe separation and turbulent transition of the flow in a compressor blade channel are investigated through direct numerical simulations (DNS) at a Reynolds number of 1.367 × 105.
Yang Liu +3 more
doaj +1 more source
Selected results on Strong and Coulomb-induced correlations from the STAR experiment
, 2007 Using recent high-statistics STAR data from Au+Au and Cu+Cu collisions at full RHIC energy I discuss strong and Coulomb-induced final state interaction effects on identical ($\pi-\pi$) and non-identical ($\pi-\Xi$) particle correlations. Analysis of $\pi-
Barnby, Lee +6 more
core +2 more sources
A New Method of Blind Source Separation Using Single-Channel ICA Based on Higher-Order Statistics [PDF]
, 2015 Guangkuo Lu +3 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Charge-statistics separation and probing non-Abelian states [PDF]
, 2008 D. E. Feldman, Feifei Li
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
On separation of monetary and fiscal operations in macroeconomics statistics [PDF]
, 2022 Václav Rybáček, Julius Janáček
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source