Results 11 to 20 of about 11,256 (144)

Neolignan Kadsurenin F Modulates Proteostatic Pathways and Possesses Potent Anti-Inflammatory Properties. [PDF]

Chem Biodivers
Abstract Kadsurenin F, a natural neolignan‐type compound, has been described as a constituent of various members of the Lauraceae family such as Aniba spp. or Nectandra spp., but can also be found in various Piper species such as Piper kadsura Ohwi (Piperaceae).
Evangelakou Z, Schwaiger S, Gianniou DD, Trougakos IP, Stuppner H.   +4 more
europepmc   +2 more sources

Rapid Unambiguous Structure Elucidation of Streptnatamide A, a New Cyclic Peptide Isolated from A Marine‐derived Streptomyces sp

Chemistry – A European Journal, Volume 29, Issue 56, October 9, 2023., 2023
An inspiring collaboration between pharmaceutical industry and academia enabled discovery, structure elucidation, and biosynthetic pathway analysis of streptnatamide A, a new cyclic peptide isolated from secondary metabolites of a marine invertebrate‐associated Streptomyces sp.
Jia‐Xuan Yan, Qihao Wu, Mitasree Maity, Doug R. Braun, Imraan Alas, Xiao Wang, Xing Yin, Yanlong Zhu, Bailey A. Bell, Scott R. Rajski, Ying Ge, Douglas D. Richardson, Wendy Zhong, Tim S. Bugni   +13 more
wiley   +1 more source

Two‐step isolation of the two major paraconic acids of Cetraria islandica

Journal of Separation Science, Volume 46, Issue 6, March 2023., 2023
The lichen Cetraria islandica is traditionally used as a demulcent for the symptomatic treatment of irritations of the mouth and throat and associated dry cough, as well as for the treatment of temporary loss of appetite. In addition to depsides and depsidones, thalli contain paraconic acids, a group of secondary metabolites commonly found in lichens ...
Eduardo Villicaña González, Stefan Schwaiger, Hermann Stuppner   +2 more
wiley   +1 more source

The Structure of Hemicalide from the Marine Sponge Hemimycale sp

European Journal of Organic Chemistry, Volume 2022, Issue 25, July 7, 2022., 2022
Hemicalide, isolated from the marine sponge Hemimycale sp., is a very potent cytotoxic compound from a marine sponge with an original mode of action. Its planar structure has been established by NMR and a proposal for 17 of its 21 stereogenic centers is made on the basis of syntheses of analogues.
Laurence Marcourt, Georges Massiot
wiley   +1 more source

GNPS‐Guided Discovery of Madurastatin Siderophores from the Termite‐Associated Actinomadura sp. RB99**

Chemistry – A European Journal, Volume 28, Issue 36, June 27, 2022., 2022
Metabolomic analysis of cocultures of Actinomadura sp. RB99 with fungal symbionts of termites allowed for the MS‐guided isolation of four unreported madurastatin derivatives, including a siderophore‐metal complex thereof. Abstract In this study, we analyzed if Actinomadura sp.
Seoung Rak Lee, Felix Schalk, Jan W. Schwitalla, Huijuan Guo, Jae Sik Yu, Moonyong Song, Won Hee Jung, Z. Wilhelm de Beer, Christine Beemelmanns, Ki Hyun Kim   +9 more
wiley   +1 more source

Characterization of the diastaphenazine/izumiphenazine C biosynthetic gene cluster from plant endophyte Streptomyces diastaticus W2

Microbial Biotechnology, Volume 15, Issue 4, Page 1168-1177, April 2022., 2022
In this study, we identified the diastaphenazine/izumiphenazine C biosynthetic gene cluster through heterologous expression and gene inactivation. The putative biosynthetic pathway of these two compounds was proposed by further functional analysis. Significantly, the polyketide cyclase Dap5 has been proven to be responsible for the dimerization of two ...
Junli Dong, Beibei He, Ruinan Wang, Xiuli Zuo, Rui Zhan, Linfang Hu, Yiqing Li, Jing He   +7 more
wiley   +1 more source

Chemical Constituents of the Bark of Zanthoxylum gilletii (Rutaceae) and Their In Vitro Antiplasmodial and Molecular Docking Studies

Journal of Chemistry, Volume 2022, Issue 1, 2022., 2022
The phytochemical investigations of the methanol extract of Zanthoxylum gilletii bark led to the isolation of thirteen compounds identified as two alkaloids including one acridone 5‐hydroxynoracronycine (1) and one benzo [c] phenanthridine decarine (2), three lignans trans‐ and cis‐fagaramide (3 and 4) and sesamin (5), two coumarins scoparone (6) and ...
Liliane Clotilde Dzouemo, Gervais Mouthé Happi, Sikiru Akinyeye Ahmed, Willifred Dongmo Tekapi Tsopgni, Michael Nde Akuma, Shina Salau, Emmanuel Ngeufa Happi, Jean Duplex Wansi, Vinod Kumar Tiwari   +8 more
wiley   +1 more source

Biological Properties of Aloysia gratissima (Gillies & Hook.) Tronc. (Verbenaceae)

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Aloysia gratissima is a plant native to America, with applications in folk medicine for a wide range of diseases, such as bronchial infections, lung disorders, nervous system disorders (depression, anxiety), and inflammatory processes, among others. However, investigations about this species and its biological actions are still scarce.
Maryelen Alijar Souza, Fernanda Petry, Letícia Vidor Morgan, Jacir Dal Magro, Liz G. Müller, Carlos H. G. Martins   +5 more
wiley   +1 more source

Antioxidant and Anti‐Inflammatory Activities of Phytochemicals from Ruellia tuberosa

Journal of Chemistry, Volume 2022, Issue 1, 2022., 2022
In Vietnam, the aerial parts of Ruellia tuberosa L. are used to treat stress oxidation and inflammatory symptoms in diabetes mellitus. The present study was designed to determine the antioxidant and inflammatory inhibition activities of Ruellia tuberosa L. extract (RTE) and those of the isolated compounds by column chromatography.
Trinh Nhat Thi Pham, Tuan Trong Nguyen, Thuy Le Thi Nguyen, An Minh Nguyen Tran, Tuan Ngoc Nguyen, Danh Thanh Tong, Dung Tien Le, Andrea Mastinu   +7 more
wiley   +1 more source

Dual Biological Potential: Anticancer and Antibacterial Activities of Bis-α, ω-Bifunctional Sphingolipids from the Marine Sponge Oceanapia ramsayi. [PDF]

ChemMedChem
Preparative work on Oceanapia ramsayi sponge specimens collected from the northeast South African coast (A) result in the isolation of four bifunctional sphingolipids (center). Bioassays of these compounds and their derivatives (B) show antimicrobial activity against bacterial pathogens and selective cytotoxicity to breast cancer tissue culture cell ...
Keneni DA, Njanje I, Kalinski JJ, Isaacs M, Swart T, Davison C, de la Mare JA, Dorrington RA.   +7 more
europepmc   +2 more sources