Results 61 to 70 of about 2,210 (155)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Effects of Sepiapterin Supplementation and NOS Inhibition on Glucocorticoid-Induced Hypertension

, 2016
Glucocorticoid-induced hypertension is associated with imbalance between nitric oxide (NO) and superoxide. One of the pathways that causes this imbalance is endothelial NO synthase (eNOS) uncoupling.
Mori, Trevor A, Croft, Kevin D, Wang, Hans, Earl, John, Vickers, Janine, Zhang, Yi, Whitworth, Judith, Thida, Mya, Zhao, Yan, Tse, Chi-Sum (Sammy), Ong, Sharon, Sutton, Matthew   +11 more
core   +1 more source

Cloning And Ontogenic Expression Of Sepiapterin Reductase Mrna In Zebrafish Embryo : Possible Role In Pteridine Biosynthesis [QL767. K95 2008 f rb]. [PDF]

, 2008
Sepiapterin reductase (SR, EC1.1.1.153) memangkinkan langkah terakhir di dalam laluan biosintesis de novo bagi tetrahidrobiopterin (BH4), yang mana merupakan kofaktor sangat penting untuk penghasilan pteridin di dalam kromatofor teleost.
Kuah, Meng Kiat
core   +1 more source

A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila. [PDF]

PLoS Biology, 2017
Here, we show that the enzymatic cofactor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila. BH4 biosynthesis requires the sequential action of the conserved enzymes Punch, Purple, and Sepiapterin Reductase (Sptr).
Do-Hyoung Kim, Minjung Shin, Sung-Hwan Jung, Young-Joon Kim, Walton D Jones   +4 more
doaj   +1 more source

Age‐Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kana Kitayama, Tomoko Sakaguchi, Noriko Nakano, Daijiro Kabata, Haruo Shintaku, Takashi Hamazaki   +5 more
wiley   +1 more source

Brain Age in Adult Patients With Early‐Treated Phenylketonuria

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Structural brain alterations have been observed in individuals with phenylketonuria (PKU); however, the potential impact of PKU on brain aging remains unexplored. This study investigated brain age in adults with early‐treated classical PKU compared to healthy controls. Thirty early‐treated adults with classical PKU (age 19–48 years) and 59 age‐
Laura Winiger, Raphaela Muri, Tobias Kaufmann, Michel Hochuli, Emma Vardy, Piotr Radojewski, Katarzyna Pospieszny, Roman Trepp, Regula Everts   +8 more
wiley   +1 more source

L-sepiapterin restores SLE serum-induced markers of endothelial function in endothelial cells

Lupus Science and Medicine, 2019
Objective SLE serves as an independent risk factor` for endothelial dysfunction (ED) not explained by Framingham risk factors. We sought to understand the development of SLE-induced ED on a cellular level in order to develop strategies aimed at reversing
Jim C Oates, Joy N Jones Buie, Dorea Pleasant Jenkins, Robin Muise-Helmericks   +3 more
doaj   +1 more source

Pigments, Chromatophore Structure, and Gene Expression Underlying Colour Polytypy of a Panamanian Poison Frog

Molecular Ecology, Volume 35, Issue 1, January 2026.
ABSTRACT Colour polytypism represents an example of phenotypic diversification shaped by genetic divergence and ecological pressures. Poison frogs of the genus Oophaga (Dendrobatidae) are highly polytypic in coloration, making them an ideal system for investigating the genetic and physiological basis of colour variation.
Vasiliki Mantzana‐Oikonomaki, Giselle Tamayo‐Castillo, Víctor Vásquez‐Cháves, Abel Mora‐Machado, William J. Zamora Ramirez, Roberto Ibáñez, Heike Pröhl, Ariel Rodríguez   +7 more
wiley   +1 more source

Characterization of the Protective Effect of Tetrahydrobiopterin Against S-Nitroso-N -Acetyl-D ,L-Penicillamine Induced Endothelial Cell Injury

Pteridines, 1999
The purpose of this study was to characterize the protective effect of tetrahydrobiopterin (BH4), one of the cofactors of nitric oxide (NO) synthase, against NO-induced endothelial cell injury. The addition of S-nitroso-N-acetyl-D,L-penicillamine (SNAP),
Ishii Masakazu, Shimizu Shunichi, Momose Kazutaka, Kiuchi Yuji, Yamamoto Toshinori   +4 more
doaj   +1 more source

Levodopa Use and Long‐Term Benefit in Different Dystonia Phenotypes

Acta Neurologica Scandinavica, Volume 2026, Issue 1, 2026.
Background Dopaminergic changes have been reported in various forms of dystonia beyond dopa‐responsive dystonia (DRD). Besides DRD, levodopa (LDopa) is generally not considered effective in dystonia and may worsen it. This study assesses the impact of LDopa on different dystonia phenotypes. Objectives The patient database of Tampere University Hospital
Rebekka M. Ortiz, Jari Honkaniemi, Gessica Sala   +2 more
wiley   +1 more source