Results 41 to 50 of about 2,210 (155)

Tetrahydrobiopterin Uptake in Supplemental Administration: Elevation of Tissue Tetrahydrobiopterin in Mice Following Uptake of the Exogenously Oxidized Product 7,8-Dihydrobiopterin and Subsequent Reduction by an Anti-folate-Sensitive Process

Journal of Pharmacological Sciences, 2004
In order to increase the tissue level of tetrahydrobiopterin (BH4), supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the effectiveness of 6RBH4 was compared with 7,8-dihydrobiopterin (7,8BH2) and sepiapterin by ...
Keiko Sawabe, Kazunori Osuke Wakasugi, Hiroyuki Hasegawa   +2 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Global Proteomic Analysis of Sperm and Seminal Plasma From Tropically‐Adapted Rams With Contrasting Parameters of Frozen‐Thawed Semen

Molecular Reproduction and Development, Volume 93, Issue 10, October 2026.
ABSTRACT The aim of this study was to characterize the proteome of sperm and seminal plasma (SP) from rams with high semen freezability (HF) and low semen freezability (LF). Eleven ejaculates were collected from 12 rams, at 3‐day intervals, and cryopreserved (132 semen samples).
Wallisson Bruno de Morais Pacheco, Iran Aguila Maciel, Suane Santos Alves dos Santos, Alan Martins de Araújo, Francisca Nágila Matos Almeida, Denise Damasceno Guerreiro, Sheheryar Sheheryar, Lais Lacerda Brasil de Oliveira, Felipe Domingos de Sousa, Mohibullah Shah, Maria Elisabete Amaral Moraes, Carlos Roberto Koscky Paier, Ana Cristina de Oliveira Monteiro, Carminda Sandra Brito Salmito‐Vanderley, Arlindo A. Moura   +14 more
wiley   +1 more source

Sepiapterin Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells

, 2013
In the lung, chemical redox cycling generates highly toxic reactive oxygen species that can cause alveolar inflammation and damage to the epithelium, as well as fibrosis.
Yang, Shaojun, Gray, Joshua P, Heck, Diane E, Mishin, Vladimir, Jan, Yi-Hua, Laskin, Jeffrey D, Laskin, Debra L   +6 more
core   +1 more source

Localization of Sepiapterin Deaminase and Pteridines In the Granules In Epidermal Cells of the Silkworm, Bombyx mori

Pteridines, 1990
A new method for assay of sepiapterin deaminase (3.5.4.24) activity by use of high performance liquid chromatography (HPLC) was developed. By this sensitive method the enzyme activity in the cell organelle was assayed.
Tsusué M., Kuroda S., Sawada H.
doaj   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin Reductase [PDF]

, 2014
Sepiapterin reductase (SPR) catalyzes the reduction of sepiapterin to dihydrobiopterin (BH2), the precursor for tetrahydrobiopterin (BH4), a cofactor critical for nitric oxide biosynthesis and alkylglycerol and aromatic amino acid metabolism.
Vladimir Mishin, Jason R. Richardson, Muhammad M. Hossain, Diane E. Heck, Shaojun Yang, Yi-hua Jan, Jeffrey D. Laskin, Ned D. Heindel, Debra L. Laskin   +8 more
core  

Sepiapterin does not reduce albuminuria in diabetic apoE KO mice.

, 2017
(A) PAS-stained glomeruli of apoE KO mice (apoE), diabetic apoE KO mice (DM) and diabetic apoE KO mice treated with sepiapterin (DM + S), showing heterogeneous diabetic lesions 14 weeks after induction of diabetes with STZ (20).
M. Cristina Avramut (3684979), Bernard M. van den Berg (358992), Ernst E. H. van Faassen (388504), Johan van der Vlag (45996), Margien G. S. Boels (561978), Ton J. Rabelink (282888)   +5 more
core   +1 more source

Two Greek siblings with sepiapterin reductase deficiency

, 2008
BACKGROUND: Sepiapterin reductase (SR) deficiency is a rare inherited disorder of neurotransmitter metabolism; less than 25 cases have been described in the literature so far.
Thöny, B; https://orcid.org/, Wevers, R A, Vargiami, E, Zafeiriou, D I, Abeling, N G G M, Verbeek, M M, Lagerwerf, A J, Willemsen, M A A P, Blau, N   +8 more
core   +2 more sources