Results 31 to 40 of about 2,210 (155)

A Comparison of Sepiapterin and Tetrahydrobiopterin Uptake by BRL2H3 Cells

Pteridines, 1996
Cellular uptake of sepiapterin and tetrahydrobiopterin was compared quantitatively with RBL2H3 cells in culture. RBL2H3 is a mast cell line and has the ability to synthesize serotonin.
Yamamoto Kazumasa, Nagano Mutsumi, Nakanishi Nobuo, Hasegawa Hiroyuki   +3 more
doaj   +1 more source

Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice. [PDF]

PLoS ONE, 2013
Tetrahydrobiopterin (BH4), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling / uncoupling.
Mathilde Dubois, Estelle Delannoy, Lucie Duluc, Ellen Closs, Huige Li, Christian Toussaint, Alain-Pierre Gadeau, Axel Gödecke, Véronique Freund-Michel, Arnaud Courtois, Roger Marthan, Jean-Pierre Savineau, Bernard Muller   +12 more
doaj   +1 more source

Detection of Sepiapterin in CSF of patients with Sepiapterin Reductase Deficiency

, 2002
Sepiapterin reductase (SR) deficiency was recently described in patients with a severe biogenic amine deficiency presenting without hyperphenylalaninemia and it was suggested that the tetrahydrobiopterin (BH4) pathway may be different in different cells ...
Redweik, Udo, Penzien, Johann M., Thöny, Beat, Blau, Nenad, Zorzi, Giovanna, Trippe, Heike   +5 more
core   +1 more source

Isolation and Characterization of Sepiapterin Reductase from Drosophila melanogaster

Pteridines, 1993
Sepiapterin reductase, an enzyme that catalyses the synthesis of tetrahydrobiopterin (BH4). was partially purified from Drosophila melanogaster using ammonium sulfate fractionation. Affi-gel blue chromatography and hydroxyapatite chromatography.
Yoon K.H., Cha K.W., Park S.I., Yim J.J.
doaj   +1 more source

Investigation of a potential role for aldose reductase AlrA in tetrahydropteridine synthesis in Dictyostelium discoideum Ax2

Pteridines, 2017
Dictyostelium discoideum Ax2 is well-known for the synthesis of d-threo-tetrahydrobiopterin (DH4) with a smaller amount of l-erythro-tetrahydrobiopterin (BH4).
Kim Hye-Lim, Ryu Hyun-Chul, Park Young Shik   +2 more
doaj   +1 more source

Effect of Sepiapterin, 7,8-Dihydrobiopterin, 5,6,7,8-Tetrahydrobiopterin and Xanthopterin on Cholesterol and Phospholipid Content and Phospholipid Biosynthesis in vitro

Pteridines, 1995
Incorporation of fatty acids into phospholipids has been investigated using samples of rat live tissue homogenate, Krebs-Ringer-phosphate buffer (pH = 7A) containing 0.3% albumin, farry acid mixture and glycerol.
Rudzite Vera, Jurika Edite, Baier-Bitterlich Gabriele, Wachter Helmut, Fuchs Dietmar   +4 more
doaj   +1 more source

Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy

Frontiers in Pharmacology, 2023
The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin, Nick A. Andrews, Alban Latremoliere   +2 more
doaj   +1 more source

Effects of Sepiapterin Infusion on Renal Oxygenation and Early Acute Renal Injury After Suprarenal Aortic Clamping in Rats

, 2011
Acute kidney injury (AKI) can occur after aortic clamping due to microvascular dysfunction leading to renal hypoxia. In this rat study, we have tested the hypothesis that the administration of the precursor of the nitric oxide synthase essential cofactor
Can Ince, Didier Payen, Asli Kandil, Payen, Didier, Matthieu Legrand, Legrand, Matthieu, Kandil, ASLI, İnce, Can   +7 more
core   +1 more source

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH₄ Pathway

, 2019
Tetrahydrobiopterin (BH4) is a cofactor in the production of various signaling molecules including nitric oxide, dopamine, adrenaline, and noradrenaline.
Olivia Jackson (3835966), Jack Blackburn (6939671), Rebecca Armitage (6939668), Patrick C. McHugh (7305878), Benjamin J. R. Moore (6939662), Barira Islam (1430641), Sean Ward (6939665), Shozeb Haider (1411420)   +7 more
core   +3 more sources

Pteridines and Lipid Metabolism

Pteridines, 1998
The effect of 9 different pteridines on fatty acid incorporation into phospholipids as well as on cholesterol and phospholipid content was compared in vitro using rat liver homogenate, Krebs-Ringer phosphate buffer containing 0.3 % albumin (pH=7.4 ...
Rudzite Vera, Jurika Edite, Baier-Bitterlich Gabriele, Widner Bernhard, Reibnegger Gilbert, Fuchs Dietmar   +5 more
doaj   +1 more source