Results 11 to 20 of about 2,210 (155)
Enzymatic Isomerization of Sepiapterin to 6-1'-Hydroxy-2' -oxopropyl 7,8-dihydropterin
Pteridines, 1989 6-1'-Hydroxy-2' -oxopropyl 7,8-dihydropterin, which has been believed to be too labile to actually exist, was produced from sepiapterin (6-lactoyl 7,8-dihydropterin).
Sueoka Terumi, Katoh Setsuko
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Sepiapterin Reductase Deficiency: Mimic of Cerebral Palsy
Pediatric Neurology Briefs, 2012 Researchers at University of California at San Diego, and 22 other US national and international centers studied the clinical, biochemical, and molecular findings in a cohort of 38 patients with sepiapterin reductase deficiency (SRD).
J Gordon Millichap
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Diagnosis and Treatment of Sepiapterin Reductase Deficiency
Pediatric Neurology Briefs, 2006 The diagnosis and long-term effects of treatment of two cases of sepiapterin reductase deficiency (SRD) are reported from Service de Neuropediatrie, CHU Montpellier, France; University de Sherbrooke, Quebec, Canada; and centers in Germany and Switzerland.
J Gordon Millichap
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Dopa-Responsive Motor Disorder with Sepiapterin Reductase Deficiency
Pediatric Neurology Briefs, 2005 The clinical findings in 7 children from Malta, at first suspected to have cerebral palsy and later diagnosed with sepiapterin reductase deficiency, are reported from Great Ormond Street Hospital, London, UK, and St Luke’s Hospital, University of Malta.
J Gordon Millichap
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An Unusual Motor OFF in Parkinson's Disease. [PDF]
Mov Disord Clin PractMovement Disorders Clinical Practice, Volume 13, Issue 4, Page 1085-1087, April 2026.
Jha S, Jog MS.
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Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status [PDF]
Frontiers in PharmacologyIntroduction6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for multiple enzymes, including phenylalanine hydroxylase (PAH). Exogenous BH4, or its natural precursor sepiapterin, is utilized to treat patients with phenylketonuria ...
Lan Gao, Neil Smith, Ronald Kong
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Biosynthesis of Pteridines in Insects: A Review [PDF]
InsectsPteridines are important cofactors for many biological functions of all living organisms, and they were first discovered as pigments of insects, mainly in butterfly wings and the eye and body colors of insects. Most of the information on their structures
Juan Ferré
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Neuropsychiatric Disease and Treatment, 2015 Jiawu Fu,1,* Guoda Ma,1,* Hui Mai,1,* Xudong Luo,2 Jingwen Yin,2 Qing Chen,2 Zhixiong Lin,2 Hua Tao,1 You Li,1 Lili Cui,1 Zheng Li,3 Juda Lin,2 Bin Zhao,1 Keshen Li1 1Institute of Neurology, Affiliated Hospital of Guangdong Medical University ...
Fu JW +13 more
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BH4 supplementation reduces retinal cell death in ischaemic retinopathy
Scientific Reports, 2023 Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxidative stress ...
Kevin S. Edgar +3 more
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Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor
Antioxidants, 2023 Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the metabolism of phenylalanine and lipid esters.
Tuany Eichwald +10 more
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