Results 21 to 30 of about 2,210 (155)
No QT interval prolongation effect of sepiapterin: a concentration-QTc analysis of pooled data from phase 1 and phase 3 studies in healthy volunteers and patients with phenylketonuria [PDF]
Journal of Pharmacokinetics and PharmacodynamicsNeil Smith, Yongjun Hu, Ronald Kong
exaly +2 more sources
Uncoupled nitric oxide synthase activity promotes colorectal cancer progression
Frontiers in Oncology, 2023 Increased levels of reactive oxygen/nitrogen species are one hallmark of chronic inflammation contributing to the activation of pro-inflammatory/proliferative pathways. In the cancers analyzed, the tetrahydrobiopterin:dihydrobiopterin ratio is lower than
Asim Alam +5 more
doaj +1 more source
Clinical Features of Families with a Novel Pathogenic Mutation in Sepiapterin Reductase. [PDF]
Int J Mol SciSepiapterin Reductase Deficiency (SRD) is a rare inherited neurometabolic disorder caused by variants in the SPR gene, which may lead to developmental delays, psychomotor retardation, and cognitive impairments. Two consanguineous North African and Middle
Mohamed FE +13 more
europepmc +2 more sources
Ruthenium nanomicellar catalysis under MW irradiation” and “Development of an alternative synthetic strategy for Sepiapterin" [PDF]
, 2022 The first project regards the academic research and have the aim to develop new sustainable synthesis through nanomicellar catalytic system assisted with MW irradiation.
Saponaro, Simone
core +1 more source
Fragment-based discovery of novel potent sepiapterin reductase inhibitors
, 2019 Genome-wide-association studies in chronic low back pain patients identified sepiapterin reductase as a high interest target for developing new analgesics.
Alen, Jo (author) +8 more
core +3 more sources
Pteridines, 2005 Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and nitric oxide synthase. The biosynthetic pathway of BH4 from 6-pyruvoyl-tetrahydropterin (PPH4) includes two reduction steps catalyzed by sepiapterin rcductasc (SPR).
Sawada Hiroshi +3 more
doaj +1 more source
6-Acetonylisoxanthopterin: A Potent Inhibitor of Sepiapterin Reductase
Pteridines, 1991 The inhibitory effect of 6-/7-substituted (2'-oxo) pteridines and ichthyopterin was examined for sepiapterin reductase. 6-Acetonylisoxanthopterin and 6-acetonyl-2,4-diamino-7-hydroxypteridine showed pronounced competitive inhibitory effects to ...
Nakanishi A. +3 more
doaj +1 more source
Molecules, 2019 In this work, we aimed to improve the encapsulation efficiency of sepiapterin (SP), the natural precursor of the essential cofactor tetrahydrobiopterin (BH4) that displays mild water-solubility and a short biological half-life, within methoxy-poly ...
Nataliya Kuplennik, Alejandro Sosnik
doaj +1 more source
Pteridines, 2006 The effect of 5,6,7,8-tetrahydrobiopterin (BH4), an endogenous antioxidant, on γ-ray-induced micronucleus frequency was examined in RAW264.7 cells. Exogenously added BH4 reduced the γ-ray-induced micronucleus frequency. Treatment with 1 mM sepiapterin, a
Hori Mayumi, Kojima Shuji
doaj +1 more source
Purification and Characterization of Sepiapterin Deaminase from the Silkworm, Bombyx mori
Pteridines, 1998 Sepiapterin deaminase has been purified approximately 6,000-told from the larval integument of the lemon mutant of the silkworm by several column chromatographic procedures.
Sawada Hiroshi +5 more
doaj +1 more source