Evaluation of the silkworm lemon mutant as an invertebrate animal model for human sepiapterin reductase deficiency [PDF]
Royal Society Open Science, 2020 Human sepiapterin reductase (SR) deficiency is an inherited disease caused by SPR gene mutations and is a monoamine neurotransmitter disorder. Here, we investigated whether the silkworm lemon mutant could serve as a model of SR deficiency.
Fangyin Dai, Xiaoling Tong
exaly +3 more sources
Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy [PDF]
Frontiers in Pharmacology, 2023 The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin +2 more
doaj +2 more sources
WSV056 Inhibits Shrimp Nitric Oxide Synthase Activity by Downregulating Litopenaeus vannamei Sepiapterin Reductase to Promote White Spot Syndrome Virus Replication [PDF]
Frontiers in Microbiology, 2021 Sepiapterin reductase (Spr) plays an essential role in the biosynthesis of tetrahydrobiopterin (BH4), a key cofactor of multiple enzymes involved in various physiological and immune processes.
Wei Wang +5 more
doaj +2 more sources
Structural and mechanistic insights into the divergence of pterin deaminase and sepiapterin deaminase [PDF]
Applied Microbiology and BiotechnologyPterin deaminase and sepiapterin deaminase are key members of the amidohydrolase superfamily and play essential roles in pteridine metabolism across a wide range of biological systems.
Nivetha Shanmuganathan +7 more
doaj +2 more sources
Association study of sepiapterin reductase gene promoter polymorphisms with schizophrenia in a Han Chinese population [PDF]
Neuropsychiatric Disease and Treatment, 2015 Jiawu Fu,1,* Guoda Ma,1,* Hui Mai,1,* Xudong Luo,2 Jingwen Yin,2 Qing Chen,2 Zhixiong Lin,2 Hua Tao,1 You Li,1 Lili Cui,1 Zheng Li,3 Juda Lin,2 Bin Zhao,1 Keshen Li1 1Institute of Neurology, Affiliated Hospital of Guangdong Medical University ...
Fu JW +13 more
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Sepiapterin reductase: Characteristics and role in diseases [PDF]
Journal of Cellular and Molecular Medicine, 2020 Ligong Lu, Yao Wu, Hongzhi Du
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Biosynthesis of Pteridines in Insects: A Review [PDF]
InsectsPteridines are important cofactors for many biological functions of all living organisms, and they were first discovered as pigments of insects, mainly in butterfly wings and the eye and body colors of insects. Most of the information on their structures
Juan Ferré
doaj +2 more sources
Follow-up and outcome of patients with primary BH4 deficiencies [PDF]
Frontiers in NeurologyBH4 deficiencies may occur with or without hyperphenylalaninemia (HPA). If identified early through neonatal screening for PKU, the clinical follow-up aims to prevent the onset of typical disease symptoms.
Francesca Nardecchia +10 more
doaj +2 more sources
Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway [PDF]
ACS Omega, 2019 Benjamin J. R. Moore +7 more
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Uncoupled nitric oxide synthase activity promotes colorectal cancer progression
Frontiers in Oncology, 2023 Increased levels of reactive oxygen/nitrogen species are one hallmark of chronic inflammation contributing to the activation of pro-inflammatory/proliferative pathways. In the cancers analyzed, the tetrahydrobiopterin:dihydrobiopterin ratio is lower than
Asim Alam +5 more
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