Results 111 to 120 of about 875,517 (356)

Effects of different dosages/frequency of Xuebijing injection (a Chinese patent) for sepsis: a network meta-analysis of randomized controlled trials

Frontiers in Medicine
ObjectiveXuebijing injection (XBJ) has been widely recognized in the treatment of sepsis, however, inadequate information regarding XBJ's optimal dosage and frequency suffice.
Guangyan Liu, Guangyan Liu, Xueping Qu, Xueping Qu, Ruowen Jiang, Ruowen Jiang, Yongxing Wu, Yongxing Wu, Zan Qin, Zan Qin, Hui Zhang, Hui Zhang, Ruze Ma, Ruze Ma, Jiawei Xue, Jiawei Xue, Junwu Wang, Junwu Wang, Xueqin Xu, Xueqin Xu, Chenxi Yan, Chenxi Yan, Xiaodan Wei, Xiaodan Wei, Litao Guo, Litao Guo   +25 more
doaj   +1 more source

Proteomic Analysis of Pediatric Hemophagocytic Lymphohistiocytosis: a Comparative Study with Healthy Controls, Sepsis, Critical Ill, and Active Epstein-Barr virus Infection to Identify Altered Pathways and Candidate Biomarkers [PDF]

, 2023
Xun Li, Ting Luo, Haipeng Yan, Longlong Xie, Yufan Yang, Ling Gong, Zhexuan Tang, Minghui Tang, Xinping Zhang, Jiaotian Huang, Mincui Zheng, Zhenya Yao, Ping Zang, Desheng Zhu, Zhenghui Xiao, Xiulan Lu   +15 more
openalex   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals [PDF]

, 2019
Importance: Sepsis is present in many hospitalizations that culminate in death. The contribution of sepsis to these deaths, and the extent to which they are preventable, is unknown.
Anderson, Deverick J, Dantes, Raymund B, Epstein, Lauren, Hamad, Yasir, Jones, Travis M, Klompas, Michael, O\u27Brien, Cara, Pande, Anupam, Rhee, Chanu, Varon, Jack, Warren, David K   +10 more
core   +1 more source

Real‐Time In Vivo Monitoring of Anastomotic Intestinal Ischemia Using Implantable Resorbable Organic Sensors

Advanced Science, EarlyView.
Resorbable impedance sensors are successfully implanted into porcine small intestinal anastomoses. Impedance was recorded for 2 hours prior, and 2 hours following ischemia induction, and a significant drop in tissue impedance was observed. Abstract Anastomotic failure remains one of the most severe complications in gastrointestinal surgery.
Dennis Wahl, Finn Jaekel, Julia Henne, Richard Kantelberg, Daniel C. Freund, Eberhard Grambow, Brigitte Vollmar, Amelie R. Zitzmann, Hans Kleemann, Jochen Hampe, Sebastian Hinz, Clemens Schafmayer, Karl Leo   +12 more
wiley   +1 more source

Different Potential of Extracellular Vesicles to Support Thrombin Generation: Contributions of Phosphatidylserine, Tissue Factor, and Cellular Origin

Scientific Reports, 2017
Cells release diverse types of vesicles constitutively or in response to proliferation, injury, inflammation, or stress. Extracellular vesicles (EVs) are crucial in intercellular communication, and there is emerging evidence for their roles in ...
Carla Tripisciano, René Weiss, Tanja Eichhorn, Andreas Spittler, Thomas Heuser, Michael Bernhard Fischer, Viktoria Weber   +6 more
doaj   +1 more source

Extracellular Vesicles from Different Sources of Mesenchymal Stromal Cells Have Distinct Effects on Lung and Distal Organs in Experimental Sepsis [PDF]

, 2023
Natália Blanco, NAOMY SOL FERNANDES MACHADO, Lígia Lins de Castro, Mariana A. Antunes, Christina Maeda Takiya, Monique R. O. Trugilho, Luana R. Silva, Adriana Franco Paes Leme, Romênia R. Domingues, Bianca Alves Pauletti, Beatriz Toja de Miranda, Johnatas D. Silva, Claúdia C. dos Santos, Pedro Leme Silva, Patrícia R. M. Rocco, Fernanda Ferreira Cruz   +15 more
openalex   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Prevalence of gram-negative infections in cervico-facial sepsis [PDF]

, 2019
Magister Chirurgiae Dentium (MChD)In cervico-facial sepsis a substantial proportion of organisms are normally gram-negative staining of which the majority are anaerobes (Boyanova 2006 and Sanchez 2010).
Barnard, Neil
core  

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source