Results 121 to 130 of about 673,315 (318)
Toward Automated Early Sepsis Alerting: Identifying Infection Patients from Nursing Notes [PDF]
arXiv, 2018 Severe sepsis and septic shock are conditions that affect millions of patients and have close to 50% mortality rate. Early identification of at-risk patients significantly improves outcomes. Electronic surveillance tools have been developed to monitor structured Electronic Medical Records and automatically recognize early signs of sepsis. However, many
arxiv
Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019
2019 Computing in Cardiology (CinC), 2019 The PhysioNet/Computing in Cardiology Challenge focused on the early detection of sepsis from clinical data. A total of 40,336 patient records from two distinct hospital systems were shared with participants while 22,761 patient records from three ...
PhD Matthew A. Reyna +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua +19 more
wiley +1 more source
Journal of Lipid Research, 2013 Plasma secretion of acid sphingomyelinase is a hallmark of cellular stress response resulting in the formation of membrane embedded ceramide-enriched lipid rafts and the reorganization of receptor complexes.
Nayla Jbeily +10 more
doaj
Infection Prevention in Practice, 2023 Summary: Introduction: Acquired carbapenemase-producing Gram-negative bacteria are an increasing public health concern globally and have been mandatory to report in England since October 2020. However, in light of the COVID-19 (SARS-CoV-2) pandemic, the
Kirsty F. Bennet +6 more
doaj
Intensive insulin therapy and pentastarch resuscitation in severe sepsis.
New England Journal of Medicine, 2008 BACKGROUND The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids ...
F. Brunkhorst +22 more
semanticscholar +1 more source
Advanced Science, EarlyView.3D culture of MSCs upregulates gene expression of matrix metalloproteinases (MMPs), growth factors (GFs), and increases the production of extracellular vesicles (EVs). Proteomic analysis reveals 642 upregulated proteins in 3D‐EVs, including HGF. These 3D‐EVs, enriched with HGF, protect lung epithelial cells from apoptosis and barrier damage in septic ...
Yong Chen +9 more
wiley +1 more source
Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis
Molecular Medicine, 2016 The pathophysiology of sepsis involves activation of acid sphingomyelinase (SMPD1) with subsequent generation of the bioactive mediator ceramide. We herein evaluate the hypothesis that the enzyme exerts biological effects in endothelial stress response ...
Ha-Yeun Chung +9 more
doaj +1 more source
Temporal Pattern Discovery for Accurate Sepsis Diagnosis in ICU Patients [PDF]
arXiv, 2017 Sepsis is a condition caused by the body's overwhelming and life-threatening response to infection, which can lead to tissue damage, organ failure, and finally death. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. Sepsis is difficult to predict, diagnose, and treat.
arxiv
Über Sepsis tuberculosa gravisimia bei einem Falle von Polycythämie [PDF]
, 1922 Karl Rennen
openalex +1 more source