Results 21 to 30 of about 326,876 (283)

Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. [PDF]

PLoS ONE, 2013
Galectin-3 protein is critical to the development of liver fibrosis because galectin-3 null mice have attenuated fibrosis after liver injury. Therefore, we examined the ability of novel complex carbohydrate galectin inhibitors to treat toxin-induced ...
Peter G Traber, Hsin Chou, Eliezer Zomer, Feng Hong, Anatole Klyosov, Maria-Isabel Fiel, Scott L Friedman   +6 more
doaj   +1 more source

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Königshoff, M., Melanie Königshoff, Königshoff, Melanie   +2 more
core   +1 more source

Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)

Memorias do Instituto Oswaldo Cruz, 2004
Rats and mice are among the most susceptible hosts for the helminth Capillaria hepatica. More information on the similarities and differences between the hepatic pathology presented by these two parasite hosts are needed, since they may represent good ...
Stelamares Boyda de Andrade, Zilton A Andrade   +1 more
doaj   +1 more source

Myocardial contrast echocardiography assessment of perfusion abnormalities in hypertrophic cardiomyopathy

Cardiovascular Ultrasound, 2022
Background Perfusion defects during stress can occur in hypertrophic cardiomyopathy (HCM) from either structural or functional abnormalities of the coronary microcirculation.
Paola Roldan, Sriram Ravi, James Hodovan, J. Todd Belcik, Stephen B. Heitner, Ahmad Masri, Jonathan R. Lindner   +6 more
doaj   +1 more source

Non-invasive ventilation and clinical outcomes in cystic fibrosis: Findings from the UK CF registry [PDF]

, 2018
Background: Non-invasive ventilation (NIV) for respiratory failure and airway clearance is an established intervention in cystic fibrosis (CF), but its therapeutic benefit on lung function and survival remains under-investigated. Methods: Using data from
Bilton, D, Banya, W, Archangelidi, O, Cullinan, P, Carr, SB, Simmonds, NJ   +5 more
core   +1 more source

Evaluation of diastolic dysfunction in children with hypertrophic cardiomyopathy and its relationship with development of myocardial fibrosis

The Egyptian Heart Journal, 2023
Background Patients with hypertrophic cardiomyopathy may develop symptoms of shortness of breathing due to diastolic dysfunction which is not related to the severity of left ventricular outflow tract obstruction.
Salem Elsayed Deraz, Omar Deyaa Esmat, Rehab Galal Abd El-Hmid, Sayed Ali Amin   +3 more
doaj   +1 more source

Experimental Right Ventricular Hypertension Induces Regional β1‐Integrin–Mediated Transduction of Hypertrophic and Profibrotic Right and Left Ventricular Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundDevelopment of right ventricular (RV) hypertension eventually contributes to RV and left ventricular (LV) myocardial fibrosis and dysfunction. The molecular mechanisms are not fully elucidated.
Mei Sun, Ryo Ishii, Kenichi Okumura, Adrienn Krauszman, Siegfried Breitling, Olga Gomez, Aleksander Hinek, Stellar Boo, Boris Hinz, Kim A. Connelly, Wolfgang M. Kuebler, Mark K. Friedberg   +11 more
doaj   +1 more source

Presence of contractile impairment appears crucial for structural remodeling in idiopathic left bundle-branch block

Journal of Cardiovascular Magnetic Resonance, 2021
Background To differentiate effects of ventricular asynchrony from an underlying hypocontractile cardiomyopathy this study aimed to enhance the understanding of functional impairment and structural remodeling in idiopathic left bundle-branch block (LBBB).
Janek Salatzki, Theresa Fischer, Johannes Riffel, Florian André, Kristóf Hirschberg, Andreas Ochs, Hauke Hund, Matthias Müller-Hennessen, Evangelos Giannitsis, Matthias G. Friedrich, Eberhard Scholz, Norbert Frey, Hugo A. Katus, Marco Ochs   +13 more
doaj   +1 more source

Hepatic capillariasis in rats: a new model for testing antifibrotic drugs

Brazilian Journal of Medical and Biological Research, 2000
Rats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time.
M.M. de Souza, L.M. Silva, A.A. Barbosa Jr., I.R. de Oliveira, R. Paraná, Z.A. Andrade   +5 more
doaj   +1 more source

MicroRNAs in fibrosis: opportunities and challenges [PDF]

, 2016
MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts ...
O'Reilly, Steven, Steven O’Reilly
core   +1 more source