Results 31 to 40 of about 10,805 (242)

Identification of iron metabolism-related genes in the circulation and myocardium of patients with sepsis via applied bioinformatics analysis

Frontiers in Cardiovascular Medicine, 2023
BackgroundEarly diagnosis of septic cardiomyopathy is essential to reduce the mortality rate of sepsis. Previous studies indicated that iron metabolism plays a vital role in sepsis-induced cardiomyopathy. Here, we aimed to identify shared iron metabolism-
Renlingzi Zhang, Chong Di, Hanlu Gao, Yunlou Zhu, Congye Li, Zhengfang Zhu, Qixing Wang, Junjie Wang, Feng Zhou, Sheng Wang   +9 more
doaj   +1 more source

Receptor-Interacting Protein Kinase 3 Suppresses Mitophagy Activation via the Yes-Associated Protein/Transcription Factor EB Pathways in Septic Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
Mitophagy, known as the main mechanism of mitochondrial quality control, determines the pathophysiology of septic cardiomyopathy, although the precise regulatory mechanisms remain elusive.
Pingjun Zhu, Yangxiaocao Chen, Junyan Wang, Geng Lin, Geng Lin, Runsheng Wang, Runsheng Wang, Runsheng Wang, Yifan Que, Yifan Que, Jin Zhou, Guogang Xu, Jiang Luo, Yingzhen Du   +13 more
doaj   +1 more source

Melatonin as a potential treatment for septic cardiomyopathy

Biomedicine & Pharmacotherapy, 2023
Septic cardiomyopathy (SCM) is a common complication of sepsis contributing to high mortality rates. Its pathophysiology involves complex factors, including inflammatory cytokines, mitochondrial dysfunction, oxidative stress, and immune dysregulation. Despite extensive research, no effective pharmacological agent has been established for sepsis-induced
Amira Mohamed, Taha, Abdelrahman Mohamed, Mahmoud, Mohamed M, Ghonaim, Ateeba, Kamran, Jehad Feras, AlSamhori, Majd M, AlBarakat, Abhigan Babu, Shrestha, Vikash, Jaiswal, Russel J, Reiter   +8 more
openaire   +2 more sources

Advances in mitochondria-nucleus crosstalk in septic cardiomyopathy. [PDF]

Cell Biol Toxicol
Sepsis-induced cardiomyopathy (SICM), a critical contributor to the high mortality rate associated with sepsis, involves complex pathophysiological mechanisms that remain incompletely elucidated. In recent years, dysregulation of bidirectional signaling communication between mitochondria and the nucleus has been recognized as a pivotal factor in the ...
Chen W, Zhao Z, Geng Z, Zhang H, Fu X.
europepmc   +3 more sources

A multicenter prospective cohort study of cardiac ultrasound phenotypes in patients with sepsis: Study protocol for a multicenter prospective cohort trial

Frontiers in Medicine, 2022
BackgroundSepsis-induced cardiomyopathy significantly increased the mortality of patients with sepsis. The diagnostic criteria for septic cardiomyopathy has not been unified, which brings serious difficulties to clinical treatment.
Hongxuan Zhang, Xiaoting Wang, Wanhong Yin, Hongmin Zhang, Lixia Liu, Pan Pan, Ying Zhu, Wei Huang, Zhiqun Xing, Bo Yao, Cui Wang, Tianlai Lin, Rongguo Yu, Xiuling Shang   +13 more
doaj   +1 more source

Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy

Frontiers in Cell and Developmental Biology, 2021
High morbidity and mortality are the most typical characteristics of septic cardiomyopathy. We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. miR-22 cardiac-specific knockout (miR-22cKO) mice and miR-
Runze Wang, Runze Wang, Yuerong Xu, Wei Zhang, Yexian Fang, Tiqun Yang, Tiqun Yang, Di Zeng, Ting Wei, Jing Liu, Haijia Zhou, Yan Li, Zhan-peng Huang, Zhan-peng Huang, Mingming Zhang   +14 more
doaj   +1 more source

Landscape of co-expressed genes between the myocardium and blood in sepsis and ceRNA network construction: a bioinformatic approach

Scientific Reports, 2023
Septic cardiomyopathy is a serious complication of sepsis. The mechanism of disease pathogenesis, which is caused by infection, is well researched.
Qi Long, Gang Li, Qiufen Dong, Min Wang, Jin Li, Liulin Wang   +5 more
doaj   +1 more source

Time Series Transcriptomic Analysis by RNA Sequencing Reveals a Key Role of PI3K in Sepsis-Induced Myocardial Injury in Mice

Frontiers in Physiology, 2022
Septic cardiomyopathy is the main complication and cause of death of severe sepsis with limited therapeutic strategy. However, the molecular mechanism of sepsis-induced cardiac injury remains unclear.
Xiao Yan, Xiao Yan, Yun-Long Zhang, Xiao Han, Pang-Bo Li, Shu-Bin Guo, Hui-Hua Li   +6 more
doaj   +1 more source

Involvement of Mitochondrial Disorders in Septic Cardiomyopathy [PDF]

Oxidative Medicine and Cellular Longevity, 2017
Sepsis is defined as a life‐threatening organ dysfunction caused by a dysregulated host response to infection. It remains a leading cause of death worldwide, despite the development of various therapeutic strategies. Cardiac dysfunction, also referred to as septic cardiomyopathy, is a frequent and well‐described complication of sepsis and associated ...
Durand, Arthur, Duburcq, Thibault, Dekeyser, Thibault, Neviere, Remi, Howsam, Michael, Favory, Raphael, Preau, Sebastien   +6 more
openaire   +4 more sources

Successful use of combined blood purification techniques in splenectomised patient with septic shock in streptococcus pneumoniae infection – a case report

BMC Infectious Diseases, 2018
Background Septic cardiomyopathy represents cardiac impairment in sepsis and is a part of systemic involvement in sepsis. Cytokine storm is responsible for septic shock and for myocardial dysfunction of potentially reversible septic cardiomyopathy ...
Andreja Sinkovic, Barbara Kit, Andrej Markota   +2 more
doaj   +1 more source