Frontiers in Cardiovascular Medicine, 2023 BackgroundThe immune infiltration and molecular mechanisms underlying septic cardiomyopathy (SC) have not been completely elucidated. This study aimed to identify key genes related to SC and elucidate the potential molecular mechanisms.MethodsThe ...
Dunliang Ma +5 more
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Ferroptosis in Septic Cardiomyopathy Is Alleviated by Ondansetron: The Critical Role of the HTR3A-ATF3 Axis in Mitochondrial and Oxidative Homeostasis [PDF]
BiomedicinesBackground: Emerging evidence has established ferroptosis as a vital factor in the pathogenesis of cardiovascular diseases, especially in septic cardiomyopathy (SCM).
Xinyun Wang +10 more
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DANCR promotes septic cardiomyopathy by enhancing macrophage glycolytic reprogramming via the IGF2BP2/HK2 axis [PDF]
Frontiers in Cell and Developmental BiologyBackgroundMetabolic reprogramming of macrophages shapes their phenotypic plasticity and contributes to the progression of septic cardiomyopathy. This study investigated the role of DANCR in modulating of macrophage glycolysis, thereby elucidating its ...
Chunhui Ma +4 more
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The potential mechanism of mitochondrial dysfunction in septic cardiomyopathy [PDF]
Journal of International Medical Research, 2018 Septic cardiomyopathy is one of the most serious complications of sepsis or septic shock. Basic and clinical research has studied the mechanism of cardiac dysfunction for more than five decades.
Pan Pan, Xiaoting Wang, Dawei Liu
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Redox Biology, 2019 The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet been completely clarified. Disease-specific treatments are lacking, and care is still based on supportive modalities.
Jiankai Zhong, Ying Tan, Jichen Liu
exaly +3 more sources
Adjunctive dobutamine in patients with septic cardiomyopathy and tissue hypoperfusion: a blinded randomised controlled multicentre trial study protocol of the ADAPT-dobutamine trial [PDF]
BMJ OpenIntroduction Sepsis-induced left ventricular (LV) dysfunction participates in cardiovascular dysfunction and associated organ failure in patients with septic shock.
Bruno Giraudeau +6 more
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Analysis of the role and mechanism of EGCG in septic cardiomyopathy based on network pharmacology [PDF]
PeerJ, 2022 Background Septic cardiomyopathy (SC) is a common complication of sepsis that leads to an increase in mortality. The pathogenesis of septic cardiomyopathy is unclear, and there is currently no effective treatment.
Ji Wu +9 more
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Septic cardiomyopathy: characteristics, evaluation, and mechanism
Emergency and Critical Care Medicine, 2022 . Sepsis is a common clinical disease; if there is no early active treatment, it is likely to develop into multiple organ dysfunction syndrome and even cause death.
Wanlin Xue +5 more
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Sepsis-related cardiomyopathy: Not an easy task for ICU physicians
Journal of Intensive Medicine, 2022 Sepsis-induced myocardial dysfunction is common. In addition to acute coronary syndrome, at least two types of left ventricular dysfunction can occur in septic patients: typical septic cardiomyopathy (SC) and sepsis-related takotsubo cardiomyopathy (ST).
Hongmin Zhang, Dawei Liu
doaj +1 more source
Septic cardiomyopathy: A narrative review
Revista Portuguesa de Cardiologia, 2023 Sepsis is a systemic inflammatory response syndrome of suspected or documented infectious origin, whose outcome is multiorgan failure. Sepsis-induced myocardial dysfunction (SIMD), present in more than 50% of septic patients, is characterized by (i) left ventricular (LV) dilatation with normal or low filling pressure, (ii) right and/or LV (systolic and/
Maria Rita Lima, Doroteia Silva
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