Engineered exosomes: a potential therapeutic strategy for septic cardiomyopathy [PDF]
Frontiers in Cardiovascular MedicineSeptic cardiomyopathy, a life-threatening complication of sepsis, can cause acute heart failure and carry a high mortality risk. Current treatments have limitations.
Fenghua Ding +2 more
exaly +4 more sources
Emerging roles of microRNAs in septic cardiomyopathy
Frontiers in Pharmacology, 2023 As one of the serious complications of sepsis, septic cardiomyopathy has gained more and more attention, because of its high morbidity and mortality. With the in-depth study of septic cardiomyopathy, several methods have been adopted clinically but have ...
Mingyan Wu +3 more
exaly +3 more sources
Septic cardiomyopathy: Fact or fiction? [PDF]
American Heart Journal PlusSeptic cardiomyopathy (SCM) represents a dynamic form of myocardial dysfunction occurring in the setting of sepsis. Unlike chronic ischemic or structural heart disease, SCM arises acutely due to a complex interplay of inflammatory, metabolic, endothelial,
Alyssa Naimi +7 more
doaj +2 more sources
Cardiomyocyte USP20 alleviates septic cardiomyopathy by deubiquitinating and inhibiting NLRP3 activity [PDF]
Clinical and Translational MedicineObjectives Although extensive research on septic cardiomyopathy has been conducted, effective therapies are still limited. Ubiquitin‐specific peptidase 20 (USP20), a deubiquitinating enzyme, is critical in regulating protein ubiquitination and various ...
Shanshan Dai +10 more
doaj +2 more sources
Prognostic value of TAPSE in patients with septic cardiomyopathy: a retrospective observational cohort study [PDF]
Frontiers in MedicineBackgroundSeptic cardiomyopathy is an acute myocardial injury caused by sepsis with high mortality. Tricuspid annular plane systolic excursion (TAPSE) is an important parameter for evaluating right ventricular systolic function, but its relationship with
Haiyun Liu +7 more
doaj +2 more sources
Case Report: Amiodarone-triggered refractory ventricular fibrillation storm in septic cardiomyopathy with pre-existing QT prolongation: termination using lidocaine and anisodamine [PDF]
Frontiers in MedicineBackgroundSeptic cardiomyopathy (SCM) is a reversible acute cardiac dysfunction caused by sepsis. The use of QT-prolonging agents such as moxifloxacin and amiodarone may induce life-threatening arrhythmias, including torsades de pointes (TdP) and ...
Min Wu, Lutao Xie, Pin Lan, Meisong Chen
doaj +2 more sources
Reviews in Cardiovascular MedicineSepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-induced myocardial dysfunction represents reversible myocardial dysfunction which ultimately results in left ventricular dilatation or ...
Ivana Lukić +8 more
doaj +2 more sources
Investigating immune dysregulation and hub genes in septic cardiomyopathy development [PDF]
Scientific ReportsSeptic cardiomyopathy is a life-threatening heart dysfunction caused by severe infection. Considering the complexity of pathogenesis and high mortality, the identification of efficient biomarkers are needed to guide clinical practice.
Wenli Li +8 more
doaj +2 more sources
Septic cardiomyopathy: Diagnosis and management
Journal of Intensive Medicine, 2022 There is an extensive body of literature focused on sepsis-induced myocardial dysfunction, but results are conflicting and no objective definition of septic cardiomyopathy (SCM) has been established.
Florence Boissier, Nadia Aissaoui
exaly +3 more sources
5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy [PDF]
Scientific ReportsAt present, there are currently no molecular biomarkers for the early diagnosis of sepsis cardiomyopathy (SCM) in clinical practice. This study focuses on an in-depth examination of the DNA hydroxymethylation profiles within plasma extracellular vesicles
Baixin Zhen +7 more
doaj +2 more sources