Results 91 to 100 of about 100,466 (204)
Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery
Aggregate, EarlyView.This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail +5 more
wiley +1 more source
Endothelin-1 and blood pressure after inhibition of nitric oxide synthesis in human septic shock [PDF]
, 1999 BACKGROUND: The systemic hypotension during human sepsis has been ascribed to increased production of nitric oxide (NO). Therefore, inhibitors of NO synthesis have been used in the treatment of hypotension in patients with
Avontuur, J.A.M. +4 more
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Aggregate, EarlyView.Diabetic wound healing is blocked by persistent inflammation and oxidative stress. Bioactive substances like growth factors and Hsts promote repair but lack long‐term stability. Herein, a platelet membrane‐coated nanoparticle system (PNP) is proposed to achieve enhanced retention of aggregation‐induced emissive (AIE) molecular‐modified Hst1 (Hst1‐AIE ...
Xiaoxuan Lei +9 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.This study explores social immunity in gregarious locusts using a groundbreaking animal–robot–pathogen interaction model. By comparing locust responses to biomimetic agents mimicking healthy and infected individuals, significant behavioral changes are revealed.
Donato Romano, Cesare Stefanini
wiley +1 more source
Prenatal Brain Abnormalities in Sodium‐Dependent Multivitamin Transporter Deficiency
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT In treatable neurometabolic disorders, early diagnosis and prompt initiation of treatment are key to improved survival and outcomes. Biallelic variants in SLC5A6 cause sodium‐dependent multivitamin transporter deficiency (OMIM # 618973), which is treatable with high‐dose pantothenic acid, biotin, and alpha lipoic acid.
Eri Ogawa +2 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Objective There is limited consensus on endoscopic skull base surgery (ESBS) reconstruction principles. This study aims to generate comprehensive themes regarding ESBS reconstruction by pooling the experiences of ESBS experts, with comparison to a literature review of current published evidence.
Edward C. Kuan +77 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat +6 more
wiley +1 more source
The effect of physiologic dose of intravenous hydrocortisone in patients with refractory septic shock: a randomized control trial [PDF]
Objective: Septic shock is a response to infection and tissue hypoperfusion which does not respond to fluid therapy and eventually leads to organ dysfunction.
Morteza Talebi Doluee1 , Maryam Salehi2 , Azadeh Mahmoudi Gharae,
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Animal Models and Experimental Medicine, EarlyView.This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin +9 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective To compare clinical and radiological outcomes among relapsing multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT), alemtuzumab (ATZ), and ocrelizumab (OCR). Methods From a London (UK) hospital‐based observational cohort, modeled data were obtained from 621 relapsing–remitting multiple sclerosis ...
Paolo Antonio Muraro +16 more
wiley +1 more source