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Septic shock is a medical emergency and is one of the main causes of mortality in critically ill patients. Given the pathophysiological complexity of sepsis spectrum and progression in clinical settings, animal models become essential tools to improve ...
Manuela Ferrario+5 more
doaj +1 more source
The Concentration of Large Extracellular Vesicles Differentiates Early Septic Shock From Infection
Septic shock represents a subset of sepsis with severe physiological aberrations and a higher mortality rate than sepsis alone. Currently, the laboratory tools which can be used to identify the state of septic shock are limited.
Latthawan Monnamorn+6 more
doaj +1 more source
Machine Learning Algorithms for Classification of Microcirculation Images from Septic and Non-Septic Patients [PDF]
Sepsis is a life-threatening disease and one of the major causes of death in hospitals. Imaging of microcirculatory dysfunction is a promising approach for automated diagnosis of sepsis. We report a machine learning classifier capable of distinguishing non-septic and septic images from dark field microcirculation videos of patients.
arxiv +1 more source
Offline reinforcement learning with uncertainty for treatment strategies in sepsis [PDF]
Guideline-based treatment for sepsis and septic shock is difficult because sepsis is a disparate range of life-threatening organ dysfunctions whose pathophysiology is not fully understood. Early intervention in sepsis is crucial for patient outcome, yet those interventions have adverse effects and are frequently overadministered.
arxiv
Sepsis is a frequently seen diagnosis in hospital settings, which when left untreated can progress to severe sepsis and septic shock. Septic shock occurs in more than 230,000 patients in the United States annually and is the cause of more than 40,000 ...
Lauer, Lacey
core +2 more sources
Trial of early, goal-directed resuscitation for septic shock.
BACKGROUND Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock.
P. Mouncey+14 more
semanticscholar +1 more source
Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong+7 more
wiley +1 more source
Perioperative optimization of Crohn's disease
Most Crohn's disease patients require surgery during the course of their illness, especially those who experience complications. The management of perioperative medications and surgery‐related decision‐making should be individualized and patient‐centered based on a multidisciplinary approach.
Chun‐Chi Lin+10 more
wiley +1 more source
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Laura Evans+59 more
semanticscholar +2 more sources
Abstract The problems associated with septic shock are highlighted, including those which arose during a 3-year prospective study. Mortality in the first year of the study was 71 per cent, falling to 38 per cent in the third year. The reasons, for this fall are detailed. The pattern of survival times changed over the 3 years, giving rise
openaire +4 more sources