Results 161 to 170 of about 1,124,600 (388)
Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu +13 more
wiley +1 more source
Determining predictors of underlying etiology and clinical deterioration in patients with physiologic instability in the emergency department [PDF]
, 2013 Thesis (M.A.)--Boston UniversityShock is a critical state defined by inadequate oxygen delivery to tissues. It is well known in the critical care community that early diagnosis and treatment of shock are crucial to improving patient outcomes. However, in
Day, Danielle E.
core +1 more source
Hybrid blood purification strategy in pediatric septic shock [PDF]
, 2016 Gabriella Bottari +2 more
openalex +1 more source
Advanced Science, EarlyView.This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang +15 more
wiley +1 more source
Hyperglycaemia as a predictor of mortality and prolonged length of stay in severe sepsis and septic shock patients presented to red zone of emergency department, Hospital Universiti Sains Malaysia: a retrospective study [PDF]
, 2015 Introduction: Initial or at-admission hyperglycaemia is a risk marker of morbidity and mortality in many acute critical illnesses. There has been no study to evaluate hyperglycaemia in severe sepsis and septic shock in the emergency department setting.
Azil , Azlizawati
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Advanced Science, EarlyView.CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal +3 more
wiley +1 more source
Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy
Advanced Science, EarlyView.Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro +6 more
wiley +1 more source
Pathogenesis and Potential Strategies for Prevention and Treatment of Septic Shock: An Update [PDF]
, 2017 Septic shock is mediated by complex interactions of cells, cytokines, and humoral pathways. Clinical therapeutic strategies aimed at inhibiting selected pathways have been efficacious in subsets of patients.
Baumgartner, J. D. +3 more
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