Results 161 to 170 of about 148,562 (307)

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

A technique for the measurement of renal ATP in a large animal model of septic shock

, 2005
BACKGROUND: The mechanisms responsible for acute renal failure in sepsis are not understood. Measurement of tissue ATP might help to understand this process but, in the large animal, it is hampered by major technical difficulties. OBJECTIVE: To develop a
Wan, Li, Jackson, Graeme D., Pell, Gaby S., May, Clive, Bellomo, Rinaldo A., Wellard, R. Mark, Williams, John   +6 more
core  

Early combination of terlipressin and norepinephrine in the treatment of patients with septic shock. [PDF]

Clinics (Sao Paulo)
Ding Z, Li M, Chen Y.
europepmc   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Septic shock

, 2018
Septic shock continues to be a leading cause of surgical mortality. Between 1965 and 1971, 105 cases of septic shock were observed at a large teaching hospital in Glasgow.
Gray, N
core  

Probable case of anaphylaxis due to hydrocortisone in a septic shock patient. [PDF]

Ther Adv Drug Saf
Song Y, Yang N, Zhou D, Cai D.
europepmc   +1 more source

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

Animal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat, Chatsuree Suksamai, Dhammika Leshan Wannigama, Kent Doi, Wiwat Chancharoenthana, Asada Leelahavanichkul   +5 more
wiley   +1 more source

Septic Shock

, 2016
Sepsis is a frequently seen diagnosis in hospital settings, which when left untreated can progress to severe sepsis and septic shock. Septic shock occurs in more than 230,000 patients in the United States annually and is the cause of more than 40,000 ...
Lauer, Lacey
core  

Association Between Myocardial Dysfunction and Septic Shock. [PDF]

Int J Mol Sci
Pădureanu V, Caragea DC, Pîrșcoveanu DFV, Dop D, Munteanu AC, Rădulescu D, Popa DG, Forțofoiu D, Drăgoescu AN, Pădureanu R.   +9 more
europepmc   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source