Norepinephrine exerts an inotropic effect during the early phase of human septic shock [PDF]
, 2017 Olfa Hamzaoui +9 more
openalex +1 more source
Advanced Science, EarlyView.MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang +12 more
wiley +1 more source
Respiratory variation in carotid peak systolic velocity predicts volume responsiveness in mechanically ventilated patients with septic shock: a prospective cohort study [PDF]
, 2015 Miguel Ibarra‐Estrada +4 more
openalex +1 more source
Echocardiography-Guided Hemodynamic Management of Severe Sepsis and Septic Shock in Adults: A Randomized Controlled Trial [PDF]
, 2020 Walid S. Alhabashy +3 more
openalex +1 more source
Advanced Science, EarlyView.Here, the study shows for the first time that Forsythoside E (FE) can promote PKM2 tetramerization by binding to its K311 site. Furthermore, it induces metabolic reprogramming of macrophages and inhibits NLRP3 expression. Finally, it can alleviate sepsis‐induced liver injury by promoting M2 anti‐inflammatory polarization.
Bingxin Wu +8 more
wiley +1 more source
Natural killer cell activity in patients with septic shock
, 1991 Patricio Maturana +5 more
openalex +2 more sources
Comparative efficacy of vasoactive medications in patients with septic shock: a network meta-analysis of randomized controlled trials [PDF]
, 2019 Lu Cheng +6 more
openalex +1 more source
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
, 2015 Adil Rafiq Rather, B. Kasana
semanticscholar +1 more source
Advanced Science, EarlyView.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
, 2001 Manuel +15 more
semanticscholar +1 more source