Results 101 to 110 of about 4,504,319 (408)
Scaling Laws and Similarity Detection in Sequence Alignment with Gaps [PDF]
, 1998 We study the problem of similarity detection by sequence alignment with gaps, using a recently established theoretical framework based on the morphology of alignment paths.
Drasdo, Dirk +2 more
core +3 more sources
Meta-alignment of biological sequences
, 2023 Les seqüències són una de les estructures de dades més versàtils que existeixen. De forma relativament senzilla, en una seqüència de símbols es pot emmagatzemar informació de qualsevol tipus. L'anàlisi sistemàtic de seqüències es un àrea molt rica de l'algorísmica amb numeroses aproximacions desenvolupades amb éxit.
openaire +4 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
A Linear Time Quantum Algorithm for Pairwise Sequence Alignment [PDF]
arXiv, 2023 Sequence Alignment is the process of aligning biological sequences in order to identify similarities between multiple sequences. In this paper, a Quantum Algorithm for finding the optimal alignment between DNA sequences has been demonstrated which works by mapping the sequence alignment problem into a path-searching problem through a 2D graph.
arxiv
Kalign 3: multiple sequence alignment of large datasets
Bioinform., 2019 Motivation Kalign is an efficient multiple sequence alignment (MSA) program capable of aligning thousands of protein or nucleotide sequences. However, current alignment problems involving large numbers of sequences are exceeding Kalign’s original design ...
T. Lassmann
semanticscholar +1 more source
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
AIMS Biophysics, 2021 An algorithm is applied to propose a sequence–function correlation of the transmembrane domains (TMDs) of the non-structural protein 4B (NS4B) of hepatitis C virus (HCV).
Ta-Chou Huang, Wolfgang B. Fischer
doaj +1 more source
Locality Sensitive Hashing-based Sequence Alignment Using Deep Bidirectional LSTM Models [PDF]
arXiv, 2020 Bidirectional Long Short-Term Memory (LSTM) is a special kind of Recurrent Neural Network (RNN) architecture which is designed to model sequences and their long-range dependencies more precisely than RNNs. This paper proposes to use deep bidirectional LSTM for sequence modeling as an approach to perform locality-sensitive hashing (LSH)-based sequence ...
arxiv
Bethe Ansatz in the Bernoulli Matching Model of Random Sequence Alignment
, 2008 For the Bernoulli Matching model of sequence alignment problem we apply the Bethe ansatz technique via an exact mapping to the 5--vertex model on a square lattice.
A. M. Vershik +14 more
core +3 more sources
A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains
Scientific Reports, 2019 Studies on the structures and functions of individual kinases have been used to understand the biological properties of other kinases that do not yet have experimental structures.
Vivek Modi, Roland L. Dunbrack
semanticscholar +1 more source