Results 111 to 120 of about 1,276,854 (326)

Local alignment of two-base encoded DNA sequence

BMC Bioinformatics, 2009
Background DNA sequence comparison is based on optimal local alignment of two sequences using a similarity score. However, some new DNA sequencing technologies do not directly measure the base sequence, but rather an encoded form, such as the two-base ...
Merriman Barry, Homer Nils, Nelson Stanley F   +2 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A multi-objective fuzzy model based on enhanced artificial fish Swarm for multiple RNA sequences alignment

Egyptian Informatics Journal
Ribonucleic Acid (RNA) sequence alignment is a fundamental operation in bioinformatics, essential for analyzing the physicochemical and functional characteristics of RNA molecules.
Medhat A. Tawfeek, Ibrahim Alrashdi, Madallah Alruwaili, Gamal Farouk Elhady   +3 more
doaj   +1 more source

Implementation of Basic Local Alignment Search for Detection H1N1 Sequence Alignment

International Journal of Trends in Mathematics Education Research, 2019
Bioinformatics is a science that studies the management and analysis of biological information. Bioinformatics includes application of mathematics, statistics, and informatics to biological problems to solve.
Retno Tri Vulandari, Sri Siswanti, Andriani Kusumaningrum Kusumawijaya, Kumaratih Sandradewi   +3 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Efficient pairwise RNA structure prediction and alignment using sequence alignment constraints

BMC Bioinformatics, 2006
Background We are interested in the problem of predicting secondary structure for small sets of homologous RNAs, by incorporating limited comparative sequence information into an RNA folding model.
Dowell Robin D, Eddy Sean R
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Analyzing at Scale the Effects of Optimal Global Sequence Alignment on Sequence Similarity Using a GPU-Optimized Implementation of the Needleman-Wunsch Algorithm and the SBERT Module

Engineering Proceedings
Global sequence alignment remains a fundamental technique in bioinformatics, yet its large-scale application is often limited by computational demands.
Emilia Pardo, Valko Milev, Ventsislav Kolev, Maria Marinova   +3 more
doaj   +1 more source

Sequence Alignment in Molecular Biology

Journal of Computational Biology, 1998
Molecular biology is becoming a computationally intense realm of contemporary science and faces some of the current grand scientific challenges. In its context, tools that identify, store, compare and analyze effectively large and growing numbers of bio-sequences are found of increasingly crucial importance.
Apostolico, Alberto, Fiancarlo, Raffaele
openaire   +4 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source