Results 121 to 130 of about 1,296,938 (317)

Unraveling epigenetic heterogeneity across gastrointestinal adenocarcinomas through a standardized analytical framework

Molecular Oncology, EarlyView.
This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto, Hege Marie Vedeld, Guro Elisabeth Lind, Marine Jeanmougin   +3 more
wiley   +1 more source

Zero Knowledge Proof for Multiple Sequence Alignment [PDF]

arXiv
Multiple sequence alignment (MSA) is a fundamental algorithm in bioinformatics. In a situation when the alignment might need to be protected while revealing the other information such the input sequences and the alignment score, zero knowledge proof can be used.
arxiv  

Optimal sequence alignments [PDF]

, 1983
Walter M. Fitch, Temple F. Smith
openalex   +1 more source

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

Molecular Oncology, EarlyView.
The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits, Barbara Andrea Reinoehl, Renate Wagner, Peter Kuess, Franziska Eckert, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser   +7 more
wiley   +1 more source

Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments

BMC Bioinformatics, 2010
Background While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor and a similar structure; pairwise sequence alignments often fail to ...
Bass Ellen J, Smoot Michael E, Sierk Michael L, Pearson William R   +3 more
doaj   +1 more source

Amino acid sequence of the Bb fragment from human complement Factor B. Alignment of the cyanogen bromide-cleavage peptides [PDF]

, 1983
Jean Gagnon, David L. Christie
openalex   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Comparative analysis of multiple protein-sequence alignment methods. [PDF]

, 1994
Marcella A. McClure, T K Vasi, W M Fitch
openalex   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

MulBlast 1.0: a multiple alignment of BLAST output to boost protein sequence similarity analysis [PDF]

, 1996
Gilles Labesse
openalex   +1 more source