Results 211 to 220 of about 4,504,319 (408)
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Parallel DNA Sequence Alignment on High-Performance Systems with CUDA and MPI [PDF]
arXivSequence alignment is a cornerstone of bioinformatics, widely used to identify similarities between DNA, RNA, and protein sequences and studying evolutionary relationships and functional properties. The Needleman-Wunsch algorithm remains a robust and accurate method for global sequence alignment.
arxiv
An iterative method for faster sum-of-pairs multiple sequence alignment [PDF]
, 2000 Knut Reinert, Jens Stoye, Torsten Will
openalex +1 more source
Petabase-scale sequence alignment catalyses viral discovery
Nature, 2020 Robert C. Edgar +14 more
semanticscholar +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
AN ALGORITHM FOR STATISTICAL ALIGNMENT OF SEQUENCES RELATED BY A BINARY TREE [PDF]
, 2000 Jotun Hein
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
The Practical Use of the A* Algorithm for Exact Multiple Sequence Alignment [PDF]
, 2000 Martin Lermen, Knut Reinert
openalex +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Benchmarking long-read genome sequence alignment tools for human genomics applications. [PDF]
PeerJ, 2023 LoTempio J, Delot E, Vilain E.
europepmc +1 more source