Results 61 to 70 of about 1,296,938 (317)
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
BMC Bioinformatics, 2010 Background Large nucleotide sequence datasets are becoming increasingly common objects of comparison. Complete bacterial genomes are reported almost everyday. This creates challenges for developing new multiple sequence alignment methods.
Kryukov Kirill, Saitou Naruya
doaj +1 more source
A Linear Time Quantum Algorithm for Pairwise Sequence Alignment [PDF]
arXiv, 2023 Sequence Alignment is the process of aligning biological sequences in order to identify similarities between multiple sequences. In this paper, a Quantum Algorithm for finding the optimal alignment between DNA sequences has been demonstrated which works by mapping the sequence alignment problem into a path-searching problem through a 2D graph.
arxiv
PhAST : pharmacophore alignment search tool [PDF]
, 2009 We developed the Pharmacophore Alignment Search Tool (PhAST), a text-based technique for rapid hit and lead structure searching in large compound databases.
Hofmann, Bettina Petra +4 more
core
Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 [PDF]
, 2006 Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection.
Arnold, Frances H. +5 more
core +1 more source
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Locality Sensitive Hashing-based Sequence Alignment Using Deep Bidirectional LSTM Models [PDF]
arXiv, 2020 Bidirectional Long Short-Term Memory (LSTM) is a special kind of Recurrent Neural Network (RNN) architecture which is designed to model sequences and their long-range dependencies more precisely than RNNs. This paper proposes to use deep bidirectional LSTM for sequence modeling as an approach to perform locality-sensitive hashing (LSH)-based sequence ...
arxiv
Bethe Ansatz in the Bernoulli Matching Model of Random Sequence Alignment
, 2008 For the Bernoulli Matching model of sequence alignment problem we apply the Bethe ansatz technique via an exact mapping to the 5--vertex model on a square lattice.
A. M. Vershik +14 more
core +3 more sources
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source