Results 51 to 60 of about 5,258,715 (348)

Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]

, 2009
Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo, Beech, Bernardi, Bernardi, Borden, Bourhis, Callaghan, Carvalho, Condemine, Condemine, Dalessio, Doucas, E. Emmott, Evans, Everett, Everett, Everett, Fagioli, Fagioli, Hoppe, Ishov, Janderova-Rossmeislova, Jensen, K. N. Leppard, Kalderon, Kelly, Liu, M. S. Cortese, Mohan, Nevels, Peng, Romero, Salomoni, Scaglioni, Shen, Sternsdorf, Stracker, T. Rich   +37 more
core   +1 more source

A Protein Sequence Analysis Hardware Accelerator Based on Divergences

International Journal of Reconfigurable Computing, 2012
The Viterbi algorithm is one of the most used dynamic programming algorithms for protein comparison and identification, based on hidden markov Models (HMMs).
Juan Fernando Eusse, Nahri Moreano, Alba Cristina Magalhaes Alves de Melo, Ricardo Pezzuol Jacobi   +3 more
doaj   +1 more source

The EVcouplings Python framework for coevolutionary sequence analysis

bioRxiv, 2018
Summary Coevolutionary sequence analysis has become a commonly used technique for de novo prediction of the structure and function of proteins, RNA, and protein complexes.
Thomas A. Hopf, Anna G. Green, B. Schubert, Sophia Mersmann, Charlotta P I Schärfe, John Ingraham, Á. Tóth-Petróczy, Kelly P. Brock, Adam J. Riesselman, P. Palmedo, C. Kang, R. Sheridan, Eli J. Draizen, Christian Dallago, C. Sander, D. Marks   +15 more
semanticscholar   +1 more source

MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets

Nature Biotechnology, 2017
VOLUME 35 NUMBER 11 NOVEMBER 2017 NATURE BIOTECHNOLOGY performance was to combine the doublematch criterion with making k-mers as long as possible, which required finding similar and not just exact k-mers. This effectively bases our decision on up to 2 ×
Martin Steinegger, J. Söding
semanticscholar   +1 more source

Predicting diverse M-best protein contact maps

, 2015
Protein contacts contain important information for protein structure and functional study, but contact prediction from sequence information remains very challenging.
Ma, Jianzhu, Sun, Siqi, Wang, Sheng, Xu, Jinbo   +3 more
core   +1 more source

MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment

Briefings Bioinform., 2004
With its theoretical basis firmly established in molecular evolutionary and population genetics, the comparative DNA and protein sequence analysis plays a central role in reconstructing the evolutionary histories of species and multigene families ...
Sudhir Kumar, K. Tamura, M. Nei
semanticscholar   +1 more source

Protein sectors: statistical coupling analysis versus conservation

, 2014
Statistical coupling analysis (SCA) is a method for analyzing multiple sequence alignments that was used to identify groups of coevolving residues termed "sectors".
Colwell, Lucy J., Leibler, Stanislas, Tesileanu, Tiberiu   +2 more
core   +4 more sources

Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression [PDF]

, 2015
In a wide variety of bacterial restriction–modification systems, a regulatory `controller' protein (or C-protein) is required for effective transcription of its own gene and for transcription of the endonuclease gene found on the same operon.
Kneale, G. G., Mcgeehan, J. E., Shevtsov, M. B., Streeter, S. D., Swiderska, A., Thresh, S.-J.   +5 more
core   +2 more sources

Combining handcrafted and learned features using deep learning to improve protein-protein interaction prediction performance

Journal of Information and Telecommunication
Understanding protein-protein interactions (PPIs) is essential because knowledge regarding PPIs helps in determining the biochemical functions of organisms. Advances made in machine learning techniques, for example, DeepFE-PPI, GcForest-PPI, and DeepPPI,
Tran Hoai Nhan, Nguyen Phuc Xuan Quynh, Le Anh Phuong   +2 more
doaj   +1 more source

Protein Sequence Retrieval and Phylogenetic Analysis of Various α-amylase Producing Bacillus species [PDF]

International Journal Bioautomation, 2020
Due to advancements made in biotechnology, genetic manipulation and medium optimization has been possible and that has led to high yield in enzyme especially α-amylase with improvised properties that find its application suitably in detergent, laundry ...
Sonali Priyadarshini, Sukanta Kumar Pradhan, Pratima Ray   +2 more
doaj   +1 more source