Results 31 to 40 of about 2,800,473 (300)

Integrative visual analysis of protein sequence mutations [PDF]

BMC Proceedings, 2014
An important aspect of studying the relationship between protein sequence, structure and function is the molecular characterization of the effect of protein mutations. To understand the functional impact of amino acid changes, the multiple biological properties of protein residues have to be considered together.Here, we present a novel visual approach ...
Doncheva, Nadezhda, Klein, Karsten, Morris, John, Wybrow, Michael, Domingues, Francisco, Albrecht, Mario   +5 more
openaire   +4 more sources

A Protein Sequence Analysis Hardware Accelerator Based on Divergences

International Journal of Reconfigurable Computing, 2012
The Viterbi algorithm is one of the most used dynamic programming algorithms for protein comparison and identification, based on hidden markov Models (HMMs).
Juan Fernando Eusse, Nahri Moreano, Alba Cristina Magalhaes Alves de Melo, Ricardo Pezzuol Jacobi   +3 more
doaj   +1 more source

Predicting diverse M-best protein contact maps

, 2015
Protein contacts contain important information for protein structure and functional study, but contact prediction from sequence information remains very challenging.
Ma, Jianzhu, Sun, Siqi, Wang, Sheng, Xu, Jinbo   +3 more
core   +1 more source

Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases

Cell Reports, 2021
Summary: Protein kinases lie at the heart of cell-signaling processes and are often mutated in disease. Kinase target recognition at the active site is in part determined by a few amino acids around the phosphoacceptor residue. However, relatively little
David Bradley, Cristina Viéitez, Vinothini Rajeeve, Joel Selkrig, Pedro R. Cutillas, Pedro Beltrao   +5 more
doaj   +1 more source

Folding and Misfolding of Designed Heteropolymer Chains with Mutations

, 1997
We study the impact of mutations (changes in amino acid sequence) on the thermodynamics of simple protein-like heteropolymers consisting of N monomers, representing the amino acid sequence. The sequence is designed to fold into its native conformation on
Broglia, R. A., Roman, H. E., Shakhnovich, E., Tiana, G., Vigezzi, E.   +4 more
core   +2 more sources

Combining handcrafted and learned features using deep learning to improve protein-protein interaction prediction performance

Journal of Information and Telecommunication
Understanding protein-protein interactions (PPIs) is essential because knowledge regarding PPIs helps in determining the biochemical functions of organisms. Advances made in machine learning techniques, for example, DeepFE-PPI, GcForest-PPI, and DeepPPI,
Tran Hoai Nhan, Nguyen Phuc Xuan Quynh, Le Anh Phuong   +2 more
doaj   +1 more source

An Entropy-Based Alignment-Free Mathematical Framework for Protein Sequence Similarity Analysis [PDF]

EPJ Web of Conferences
In this paper, a mathematical, alignment-free framework is proposed for quantifying similarity and dissimilarity among protein sequences using their physicochemical characteristics.
Vijayalakshmi D., Muralidharan M., Rameshwar K.   +2 more
doaj   +1 more source

Analysis of protein sequences [PDF]

Genome Biology, 2000
Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.
openaire   +1 more source

Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila. [PDF]

, 2013
BackgroundEvery genome contains a large number of uncharacterized proteins that may encode entirely novel biological systems. Many of these uncharacterized proteins fall into related sequence families. By applying sequence and structural analysis we hope
Aravind, L, Axelrod, Herbert L, Bateman, Alex, Chang, Yuanyuan, Coggill, Penelope, Das, Debanu, Eberhardt, Ruth Y, Finn, Robert D, Godzik, Adam, Jaroszewski, Lukasz, Murzin, Alexey G, Xu, Qingping   +11 more
core   +2 more sources

Protein Sequence Retrieval and Phylogenetic Analysis of Various α-amylase Producing Bacillus species [PDF]

International Journal Bioautomation, 2020
Due to advancements made in biotechnology, genetic manipulation and medium optimization has been possible and that has led to high yield in enzyme especially α-amylase with improvised properties that find its application suitably in detergent, laundry ...
Sonali Priyadarshini, Sukanta Kumar Pradhan, Pratima Ray   +2 more
doaj   +1 more source