Results 11 to 20 of about 2,800,473 (300)
eLife, 2019 Diabetes is a diverse and complex disease, with considerable variation in phenotypic manifestation and severity. This variation hampers the study of etiological differences and reduces the statistical power of analyses of associations to genetics ...
Isa Kristina Kirk +20 more
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BMC Bioinformatics, 2021 Background The identification of protein families is of outstanding practical importance for in silico protein annotation and is at the basis of several bioinformatic resources.
Elena Tea Russo +2 more
doaj +1 more source
Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression [PDF]
, 2015 In a wide variety of bacterial restriction–modification systems, a regulatory `controller' protein (or C-protein) is required for effective transcription of its own gene and for transcription of the endonuclease gene found on the same operon.
Kneale, G. G. +5 more
core +2 more sources
Designing hardware for protein sequence analysis [PDF]
Bioinformatics, 2003 Abstract We present the architecture of PROSIDIS, a special purpose co-processor designed to search for the occurrence of substrings similar to a given ‘template string’ within a proteome. Actual tests show speed up figures ranging from 5 to 50 with respect to conventional general-purpose processors.
Marongiu, Alessandro +2 more
openaire +3 more sources
Coevolutionary Analysis of Protein Subfamilies by Sequence Reweighting
Entropy, 2019 Extracting structural information from sequence co-variation has become a common computational biology practice in the recent years, mainly due to the availability of large sequence alignments of protein families.
Duccio Malinverni, Alessandro Barducci
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Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 [PDF]
, 2006 Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection.
Arnold, Frances H. +5 more
core +1 more source
iSeqSearch: incremental protein search for iBlast/iMMSeqs2/iDiamond [PDF]
PeerJBackground The advancement of sequencing technology has led to a rapid increase in the amount of DNA and protein sequence data; consequently, the size of genomic and proteomic databases is constantly growing.
Hyunwoo Yoo +5 more
doaj +2 more sources
SeqCP: A sequence-based algorithm for searching circularly permuted proteins
Computational and Structural Biotechnology Journal, 2023 Circular permutation (CP) is a protein sequence rearrangement in which the amino- and carboxyl-termini of a protein can be created in different positions along the imaginary circularized sequence.
Chi-Chun Chen +4 more
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Molecular characterization and function analysis of the vitellogenin receptor from the cotton bollworm, Helicoverpa armigera (Hubner) (Lepidoptera, Noctuidae) [PDF]
, 2016 Developing oocytes accumulate plentiful yolk protein during oogenesis through receptor-mediated endocytosis. The vitellogenin receptor (VgR), belonging to the low-density lipoprotein receptor (LDLR) family, regulates the absorption of yolk protein.
Guo, Yuyuan +6 more
core +11 more sources
Species-specific analysis of protein sequence motifs using mutual information
BMC Bioinformatics, 2005 Background Protein sequence motifs are by definition short fragments of conserved amino acids, often associated with a specific function. Accordingly protein sequence profiles derived from multiple sequence alignments provide an alternative description ...
Weckwerth Wolfram +3 more
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