Results 71 to 80 of about 2,818,524 (302)

Relative evolutionary rate inference in HyPhy with LEISR [PDF]

PeerJ, 2018
We introduce LEISR (Likehood Estimation of Individual Site Rates, pronounced “laser”), a tool to infer relative evolutionary rates from protein and nucleotide data, implemented in HyPhy.
Stephanie J. Spielman, Sergei L. Kosakovsky Pond   +1 more
doaj   +2 more sources

Mutational analysis of the carbohydrate binding activity of the tobacco lectin [PDF]

, 2010
At present the three-dimensional structure of the tobacco lectin, further referred to as Nictaba, and its carbohydrate-binding site are unresolved. In this paper, we propose a three-dimensional model for the Nictaba domain based on the homology between ...
Barre, Annick, Lasanajak, Yi, Proost, Paul, Rouge, Pierre, Schouppe, Dieter, Smith, David F, Van Damme, Els   +6 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

AlignScape, displaying sequence similarity using self-organizing maps

Frontiers in Bioinformatics
The current richness of sequence data needs efficient methodologies to display and analyze the complexity of the information in a compact and readable manner.
Isaac Filella-Merce, Isaac Filella-Merce, Vincent Mallet, Eric Durand, Michael Nilges, Guillaume Bouvier, Riccardo Pellarin, Riccardo Pellarin   +7 more
doaj   +1 more source

Prediction of bacterial E3 ubiquitin ligase effectors using reduced amino acid peptide fingerprinting [PDF]

PeerJ, 2019
Background Although pathogenic Gram-negative bacteria lack their own ubiquitination machinery, they have evolved or acquired virulence effectors that can manipulate the host ubiquitination process through structural and/or functional mimicry of host ...
Jason E. McDermott, John R. Cort, Ernesto S. Nakayasu, Jonathan N. Pruneda, Christopher Overall, Joshua N. Adkins   +5 more
doaj   +2 more sources

Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]

, 1994
The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H., Loh, Lambert C., Lucin, Pero, Messerle, Martin, Rapp, Maria   +4 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Cloning and characterisation of the rad9 DNA repair gene from Schizosaccharomyces pombe [PDF]

, 1991
The rad9.192 DNA repair mutant from the fission yeast, Schizosaccharomyces pombe, is sensitive to both UV and ionising radiation. The rad9 gene has been cloned by complementation of the gamma-ray sensitivity of the mutant cell line.
Carr, Antony M, Lehmann, Alan R, Murray, Johanne M, Watts, Felicity Z   +3 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Protein sequence analysis in the context of drug repurposing

BMC Medical Informatics and Decision Making
Motivation Drug repurposing speeds up the development of new treatments, being less costly, risky, and time consuming than de novo drug discovery. There are numerous biological elements that contribute to the development of diseases and, as a result, to ...
Natalia García Sánchez, Esther Ugarte Carro, Lucía Prieto-Santamaría, Alejandro Rodríguez-González   +3 more
doaj   +1 more source