An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes. [PDF]
, 2018 Mass spectrometry (MS) has become a crucial technique for the analysis of protein complexes. Native MS has traditionally examined protein subunit arrangements, while proteomics MS has focused on sequence identification.
Campuzano, Iain DG +4 more
core +1 more source
Genetic Diversity and Prevalence of Porcine Circovirus Type 2 in China During 2000-2019
Frontiers in Veterinary Science, 2021 As the major pathogen for porcine circovirus-associated disease (PCVAD), porcine circovirus type 2 (PCV2) is no longer treated as an emerging virus anymore.
Ning Li +5 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
PDBFlex: exploring flexibility in protein structures. [PDF]
, 2015 The PDBFlex database, available freely and with no login requirements at http://pdbflex.org, provides information on flexibility of protein structures as revealed by the analysis of variations between depositions of different structural models of the ...
Godzik, Adam +5 more
core +1 more source
Comparison study on k-word statistical measures for protein: From sequence to 'sequence space'
BMC Bioinformatics, 2008 Background Many proposed statistical measures can efficiently compare protein sequence to further infer protein structure, function and evolutionary information. They share the same idea of using k-word frequencies of protein sequences.
Wang Tianming, Dai Qi
doaj +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
AlignmentViewer: Sequence Analysis of Large Protein Families [PDF]
F1000Research, 2020 AlignmentViewer is a web-based tool to view and analyze multiple sequence alignments of protein families. The particular strengths of AlignmentViewer include flexible visualization at different scales as well as analysis of conservation patterns and of the distribution of proteins in sequence space.
Rob Sheridan +11 more
openaire +4 more sources
Spectral Analysis of Sequence Variability in Basic-Helix-loop-helix (bHLH) Protein Domains
Evolutionary Bioinformatics, 2006 The basic helix-loop-helix (bHLH) family of transcription factors is used as a paradigm to explore structural implications of periodicity patterns in amino acid sequence variability.
Zhi Wang, William R. Atchley
doaj +1 more source
DispHScan: A Multi-Sequence Web Tool for Predicting Protein Disorder as a Function of pH
Biomolecules, 2021 Proteins are exposed to fluctuating environmental conditions in their cellular context and during their biotechnological production. Disordered regions are susceptible to these fluctuations and may experience solvent-dependent conformational switches ...
Carlos Pintado-Grima +4 more
doaj +1 more source
DeepGATGO: A Hierarchical Pretraining-Based Graph-Attention Model for Automatic Protein Function Prediction [PDF]
arXiv, 2023 Automatic protein function prediction (AFP) is classified as a large-scale multi-label classification problem aimed at automating protein enrichment analysis to eliminate the current reliance on labor-intensive wet-lab methods. Currently, popular methods primarily combine protein-related information and Gene Ontology (GO) terms to generate final ...
arxiv