Results 101 to 110 of about 2,190,860 (309)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites

RNA Biology, 2023
RNA-binding proteins are essential regulators of RNA processing and function. Translational repression assays can be used to study how they interact with specific RNA sequences by insertion of such a consensus sequence into the 5’ untranslated region of ...
Jessica Nowacki, Mateo Malenica, Stefan Schmeing, Damian Schiller, Benjamin Buchmuller, Gulshan Amrahova, Peter ‘t Hart   +6 more
doaj   +1 more source

Dynamic Model for RNA-seq Data Analysis [PDF]

arXiv, 2014
The newly developed deep-sequencing technologies make it possible to acquire both quantitative and qualitative information regarding transcript biology. By measuring messenger RNA levels for all genes in a sample, RNA-seq provides an attractive option to characterize the global changes in transcription.
arxiv  

SARS-Cov-2 RNA Sequence Classification Based on Territory Information [PDF]

arXiv, 2021
CovID-19 genetics analysis is critical to determine virus type,virus variant and evaluate vaccines. In this paper, SARS-Cov-2 RNA sequence analysis relative to region or territory is investigated. A uniform framework of sequence SVM model with various genetics length from short to long and mixed-bases is developed by projecting SARS-Cov-2 RNA sequence ...
arxiv  

The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets [PDF]

, 2008
K-homology (KH) splicing regulator protein (KSRP) is a multi-domain RNA-binding protein that regulates different steps of mRNA metabolism, from mRNA splicing to mRNA decay, interacting with a broad range of RNA sequences.
A. Ramos, Bakheet, Beuth, D. Hollingworth, Delaglio, Garcia-Mayoral, Gherzi, I. Diaz-Moreno, Lunde, M. F. Garcia-Mayoral, Makeyev, Martin, Min, Rehbein   +13 more
core   +4 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

GEE: An Informatics Tool for Gene Expression Data Explore [PDF]

Healthcare Informatics Research, 2016
ObjectivesMajor public high-throughput functional genomic data repositories, including the Gene Expression Omnibus (GEO) and ArrayExpress have rapidly expanded.
Soo Youn Lee, Chan Hee Park, Jun Hee Yoon, Sunmin Yun, Ju Han Kim   +4 more
doaj   +1 more source

High-resolution transcriptome analysis with long-read RNA sequencing [PDF]

, 2014
RNA sequencing (RNA-seq) enables characterization and quantification of individual transcriptomes as well as detection of patterns of allelic expression and alternative splicing. Current RNA-seq protocols depend on high-throughput short-read sequencing of cDNA.
arxiv   +1 more source

Editing site analysis in a gymnosperm mitochondrial genome reveals similarities with angiosperm mitochondrial genomes [PDF]

, 2010
Sequence analysis of organelle genomes and comprehensive analysis of C-to-U editing sites from flowering and non-flowering plants have provided extensive sequence information from diverse taxa.
A Zehrmann, AL Chateigner-Boutin, AL Chateigner-Boutin, Arthur Chun-Chieh Shih, Ching-Ping Lin, H Handa, JA Merwe van der, JD Palmer, JP Mower, JP Mower, K Hammani, K Oda, K Okuda, K Okuda, K Shinozaki, K Yura, M Kugita, M Kugita, M Takenaka, M Tillich, Michael Lee Salmans, ML Hayes, MP Cummings, P Giege, PG Wolf, PG Wolf, R. Michael Mulligan, RM Maier, RM Mulligan, RW Jobson, Shu-Miaw Chaw, SM Chaw, T Kubo, T Shikanai, T Tsudzuki, T Wakasugi, Y Kobayashi, Y Notsu, Yu-Wei Wu   +38 more
core   +3 more sources

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source