Results 221 to 230 of about 1,734,932 (307)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

AI foundation models for RNA biology. [PDF]

RNA Biol
Yu H, Ding Y.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer. [PDF]

Sci Adv
Karner H, Mittmann TC, Chen VW, Borah AA, Langen A, Yousefi H, Fish L, Zaro BW, Navickas A, Goodarzi H.   +9 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A metrological foundation for absolute transcriptomics using International System of Units-anchored calibrators. [PDF]

Nat Commun
Zhang Y, Yang B, Yu Y, Wang X, Niu C, Zhang Y, Liu Y, Li J, Zhang C, Yang J, Tian J, Liu Z, Tang Z, Gao Y, Zheng Y, Liu Y, Xiao T, Zhang R, Fang X, Shi L, Dong L.   +20 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Systematic identification of variant-specific RNA structure-small molecule interactions exemplified by RNA G-quadruplexes. [PDF]

Nat Commun
Miyashita E, Onizuka K, Chen Y, Yoshida H, Hatayama H, Ishikawa S, Yan P, Hasegawa T, Ozawa M, Maeta K, Nagatsugi F, Saito H, Komatsu KR.   +12 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A small polymerase ribozyme that can synthesize itself and its complementary strand. [PDF]

Science
Gianni E, Kwok SLY, Wan CJK, Goeij K, Clifton BE, Colizzi ES, Attwater J, Holliger P.   +7 more
europepmc   +1 more source