Results 31 to 40 of about 3,346,579 (352)

Stem-loop formation drives RNA folding in mechanical unzipping experiments [PDF]

PNAS 119 (3), 2022, 2022
Accurate knowledge of RNA hybridization is essential for understanding RNA structure and function. Here we mechanically unzip and rezip a 2-kbp RNA hairpin and derive the 10 nearest-neighbor base pair (NNBP) RNA free energies in sodium and magnesium with 0.1 kcal/mol precision using optical tweezers. Notably, force-distance curves (FDCs) exhibit strong
arxiv   +1 more source

Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung [PDF]

, 1990
The complete amino acid sequence of the receptor for organic calcium channel blockers (CaCB) from rabbit lung has been deduced by cloning and sequence analysis of the cDNA.
Bean, Brown, Dascal, Ellis, Eva Bosse, Flockerzi, Franz Hofmann, Glossmann, Kameyama, Kannengiesser, Martin Biel, Methfessel, Mikami, Perez-Reyes, Peter Ruth, Roger Hullin, Ruth, Sambrook, Tanabe, Tanabe, Tanabe, Triggle, Veit Flockerzi, Walter Stühmer, Welling   +24 more
core   +2 more sources

ANALYSIS OF LARGE-SCALE SEQUENCING OF SMALL RNAS [PDF]

Biocomputing 2008, 2007
The advent of large-scale sequencing has opened up new areas of research, such as the study of Piwi-interacting small RNAs (piRNAs). piRNAs are longer than miRNAs, close to 30 nucleotides in length, involved in various functions, such as the suppression of transposons in germline. Since a large number of them (many tens of thousands) are generated from
Olson, A. J., Brennecke, J., Aravin, A. A., Hannon, G. J., Sachidanandam, R.   +4 more
openaire   +4 more sources

iLearn : an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data

Briefings Bioinform., 2019
With the explosive growth of biological sequences generated in the post-genomic era, one of the most challenging problems in bioinformatics and computational biology is to computationally characterize sequences, structures and functions in an efficient ...
Zhen Chen, Pei Zhao, Fuyi Li, T. Marquez-Lago, A. Leier, Jerico Revote, Yan Zhu, D. Powell, T. Akutsu, Geoffrey I. Webb, K. Chou, Alexander Ian Smith, R. Daly, Jian Li, Jiangning Song   +14 more
semanticscholar   +1 more source

Recent advances in RNA sequence analysis [PDF]

F1000 Biology Reports, 2010
The latest high-throughput DNA sequencing technology can now be applied on a large scale to capture the complete set of mRNA transcripts in a cell, using a technique called RNA-seq. Although RNA-seq is only 2 years old, it has rapidly swept through the field of genomics, and it is now being used to analyze the transcriptomes of organisms ranging from ...
openaire   +3 more sources

RNA Sequencing Data: Hitchhiker's Guide to Expression Analysis [PDF]

Annual Review of Biomedical Data Science, 2018
Gene expression is the fundamental level at which the results of various genetic and regulatory programs are observable. The measurement of transcriptome-wide gene expression has convincingly switched from microarrays to sequencing in a matter of years.
Mark D. Robinson, Rob Patro, Simone Tiberi, Lieven Clement, Charlotte Soneson, Charlotte Soneson, Koen Van den Berge, Katharina M. Hembach, Michael I. Love   +8 more
openaire   +3 more sources

Quantifying the relationship between sequence and three-dimensional structure conservation in RNA

BMC Bioinformatics, 2010
Background In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two decades ago for proteins, which gave the fundamental grounds for developing ...
Capriotti Emidio, Marti-Renom Marc A
doaj   +1 more source

Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta [PDF]

, 1993
Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney.
Ahmad, Ahmad, Altenhofen, Bönigk, Chen, Dhallan, Dhallan, Franz Hofmann, Goulding, Hoshi, Jost Ludwig, Kaupp, Kaupp, Kozak, Ludwig, Marc Freichel, Martin Biel, Mikami, Nathan Dascal, Pittler, Roger Hullin, Ruiz, Sanger, Scherübl, Seiss-Geuder, U.Benjamin Kaupp, Veit Flockerzi, Wolfram Altenhofen   +27 more
core   +1 more source

Global analysis of RNA cleavage by 5′-hydroxyl RNA sequencing [PDF]

Nucleic Acids Research, 2015
RNA cleavage by some endoribonucleases and self-cleaving ribozymes produces RNA fragments with 5'-hydroxyl (5'-OH) and 2',3'-cyclic phosphate termini. To identify 5'-OH RNA fragments produced by these cleavage events, we exploited the unique ligation mechanism of Escherichia coli RtcB RNA ligase to attach an oligonucleotide linker to RNAs with 5'-OH ...
Kerri York, Jay R. Hesselberth, Sally E. Peach   +2 more
openaire   +3 more sources

Expanding the repertoire of human tandem repeat RNA-binding proteins.

PLoS ONE, 2023
Protein regions consisting of arrays of tandem repeats are known to bind other molecular partners, including nucleic acid molecules. Although the interactions between repeat proteins and DNA are already widely explored, studies characterising tandem ...
Agustín Ormazábal, Matías Sebastián Carletti, Tadeo Enrique Saldaño, Martín Gonzalez Buitron, Julia Marchetti, Nicolas Palopoli, Alex Bateman   +6 more
doaj   +1 more source