Results 41 to 50 of about 1,673,033 (287)

Statistical Design and Analysis of RNA Sequencing Data [PDF]

open access: yesGenetics, 2010
AbstractNext-generation sequencing technologies are quickly becoming the preferred approach for characterizing and quantifying entire genomes. Even though data produced from these technologies are proving to be the most informative of any thus far, very little attention has been paid to fundamental design aspects of data collection and analysis, namely
Paul L. Auer, Rebecca W. Doerge
openaire   +3 more sources

A Systematic Bioinformatics Workflow With Meta-Analytics Identified Potential Pathogenic Factors of Alzheimer’s Disease

open access: yesFrontiers in Neuroscience, 2020
Potential pathogenic factors, other than well-known APP, APOE4, and PSEN, can be further identified from transcriptomics studies of differentially expressed genes (DEGs) that are specific for Alzheimer’s disease (AD), but findings are often inconsistent ...
Sze Chung Yuen   +3 more
doaj   +1 more source

Sequence motifs that distinguish ATP(CTP) : tRNA nucleotidyl transferases from eubacterial poly(A) polymerases [PDF]

open access: yes, 2004
ATP(CTP):tRNA nucleotidyl transferases, tRNA maturing enzymes found in all organisms, and eubacterial poly(A) polymerases, enzymes involved in mRNA degradation, are so similar that until now their biochemical functions could not be distinguished by their
Keller, W., Martin, G.
core   +2 more sources

Hantavirus in African Wood Mouse, Guinea

open access: yesEmerging Infectious Diseases, 2006
Hantaviruses are rodentborne, emerging viruses that cause life-threatening human diseases in Eurasia and the Americas. We detected hantavirus genome sequences in an African wood mouse (Hylomyscus simus) captured in Sangassou, Guinea.
Boris Klempa   +9 more
doaj   +1 more source

Metagenomic Analysis of Marigold: Mixed Infection Including Two New Viruses

open access: yesViruses, 2021
Marigold plants with symptoms of mosaic, crinkle, leaf curl and necrosis were observed and small RNA and ribo-depleted total RNA deep sequencing were conducted to identify the associated viruses.
Hang Yin   +7 more
doaj   +1 more source

RNA sequencing analysis of the developing chicken retina

open access: yesScientific Data, 2016
AbstractRNA sequencing transcriptome analysis using massively parallel next generation sequencing technology provides the capability to understand global changes in gene expression throughout a range of tissue samples. Development of the vertebrate retina requires complex temporal orchestration of transcriptional activation and repression.
Langouet-Astrie, Christophe J.   +4 more
openaire   +2 more sources

Geometric combinatorics and computational molecular biology: branching polytopes for RNA sequences

open access: yes, 2016
Questions in computational molecular biology generate various discrete optimization problems, such as DNA sequence alignment and RNA secondary structure prediction.
Drellich, Elizabeth   +5 more
core   +1 more source

Specific and non specific hybridization of oligonucleotide probes on microarrays [PDF]

open access: yes, 2005
Gene expression analysis by means of microarrays is based on the sequence specific binding of mRNA to DNA oligonucleotide probes and its measurement using fluorescent labels. The binding of RNA fragments involving other sequences than the intended target
Binder, Hans, Preibisch, Stephan
core   +3 more sources

RNA-sequence analysis of human B-cells [PDF]

open access: yesGenome Research, 2011
RNA-sequencing (RNA-seq) allows quantitative measurement of expression levels of genes and their transcripts. In this study, we sequenced complementary DNA fragments of cultured human B-cells and obtained 879 million 50-bp reads comprising 44 Gb of sequence.
Michael Morley   +3 more
openaire   +3 more sources

Discovery of RNA secondary structural motifs using sequence-ordered thermodynamic stability and comparative sequence analysis

open access: yesMethodsX, 2023
Major advances in RNA secondary structural motif prediction have been achieved in the last few years; however, few methods harness the predictive power of multiple approaches to deliver in-depth characterizations of local RNA motifs and their potential ...
Jake M. Peterson   +4 more
doaj  

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