Results 31 to 40 of about 1,212,393 (317)

Analysis of Small RNA Sequencing Data in Plants [PDF]

, 2022
AbstractOver the past decades, next-generation sequencing (NGS) has been employed extensively for investigating the regulatory mechanisms of small RNAs. Several bioinformatics tools are available for aiding biologists to extract meaningful information from enormous amounts of data generated by NGS platforms.
Garg, V., Varshney, R.K.
openaire   +3 more sources

A Robust and Precise ConvNet for Small Non-Coding RNA Classification (RPC-snRC)

IEEE Access, 2021
Small non-coding RNAs (ncRNAs) are attracting increasing attention as they are now considered potentially valuable resources in the development of new drugs intended to cure several human diseases.
Muhammad Nabeel Asim, Muhammad Imran Malik, Christoph Zehe, Johan Trygg, Andreas Dengel, Sheraz Ahmed   +5 more
doaj   +1 more source

An Rna Sequencing Analysis of Glaucoma Genesis in Mice

Artificial Intelligence, Soft Computing and Applications, 2022
Glaucoma is the leading cause of irreversible blindness in people over the age of 60, accounting for 6.6 to 8% of all blindness in 2010, but there is still much to be learned about the genetic origins of the eye disease. With the modern development of Next-Generation Sequencing (NGS) technologies, scientists are starting to learn more about the genetic
Sharma, Jai, Bhaskar, Vidhyacharan
openaire   +2 more sources

Noncoding RNA gene detection using comparative sequence analysis

BMC Bioinformatics, 2001
Background Noncoding RNA genes produce transcripts that exert their function without ever producing proteins. Noncoding RNA gene sequences do not have strong statistical signals, unlike protein coding genes.
Eddy Sean R, Rivas Elena
doaj   +1 more source

Global analysis of RNA cleavage by 5′-hydroxyl RNA sequencing [PDF]

Nucleic Acids Research, 2015
RNA cleavage by some endoribonucleases and self-cleaving ribozymes produces RNA fragments with 5'-hydroxyl (5'-OH) and 2',3'-cyclic phosphate termini. To identify 5'-OH RNA fragments produced by these cleavage events, we exploited the unique ligation mechanism of Escherichia coli RtcB RNA ligase to attach an oligonucleotide linker to RNAs with 5'-OH ...
Peach, Sally E., York, Kerri, Hesselberth, Jay R.   +2 more
openaire   +2 more sources

An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]

, 2013
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354), Jack O Phillips, Anastasia J Callaghan, Vincent, H., Andrew R. Pickford (485355), Adam J Roberts, Louise E. Butt (485353), Stone, Carlanne, Charlotte E. Mardle (485352), Henderson, Charlotte, Adam J. Roberts (485350), Pickford, Andy, Carlanne M Stone, Roberts, Adam J., Butt, Louise, Charlotte A Henderson, Louise E Butt, Anastasia J. Callaghan (485356), Helen A Vincent, Charlotte E Mardle, Callaghan, Anastasia, Carlanne M. Stone (485351), Phillips, Jack, Jack O. Phillips (485348), Charlotte A. Henderson (485349), Gowers, Darren, Mardle, C., Andrew R Pickford, Helen A. Vincent (485347), Darren M Gowers   +29 more
core   +1 more source

Recent advances in RNA sequence analysis [PDF]

F1000 Biology Reports, 2010
The latest high-throughput DNA sequencing technology can now be applied on a large scale to capture the complete set of mRNA transcripts in a cell, using a technique called RNA-seq. Although RNA-seq is only 2 years old, it has rapidly swept through the field of genomics, and it is now being used to analyze the transcriptomes of organisms ranging from ...
openaire   +2 more sources

Quantifying the relationship between sequence and three-dimensional structure conservation in RNA

BMC Bioinformatics, 2010
Background In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two decades ago for proteins, which gave the fundamental grounds for developing ...
Capriotti Emidio, Marti-Renom Marc A
doaj   +1 more source

ScanFold: an approach for genome-wide discovery of local RNA structural elements—applications to Zika virus and HIV [PDF]

PeerJ, 2018
In addition to encoding RNA primary structures, genomes also encode RNA secondary and tertiary structures that play roles in gene regulation and, in the case of RNA viruses, genome replication.
Ryan J. Andrews, Julien Roche, Walter N. Moss   +2 more
doaj   +2 more sources

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin   +3 more
core   +1 more source